IndraLab

Statements

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"NO 2 -FAs block STING palmitoylation via S-nitro-alkylation reaction."
35127372
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"103 This will further strengthen the inflammatory response.A study by Hansen and colleagues demonstrates the potential of NO 2 -FAs to inhibit STING signaling via adduction to cysteine 88 and 91, as well as the N-terminal histidine (His18)."
34375151
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"19 NF-jB signaling in lung macrophages may be further truncated via NO 2 -FA inhibition of the STING pathway."
34375151
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"As reported by Hansen et al. in 2018, NO -FAs can be formed in response to virus infection and are able to inhibit stimulator of interferon genes (STING) signaling, leading this way to an anti-inflammatory activity against several diseases, such as, systemic lupus erythematosus, Aicardi-Goutiéres syndrome and STING-associated vasculopathy [96]."
| PMC
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"Furthermore, we show that NO 2 -FAs can inhibit STING signaling and the release of type I IFNs in response to stimulation with the STING agonists, dsDNA and cGAMP, in addition to infection with the DNA virus HSV-2."
30061387
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"Additionally, NO 2 -FA treatment of immortalized fibroblasts from SAVI patients led to decreased STING dependent type I IFN responses."
30061387