IndraLab

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"Interestingly, Nitro-fatty acids (NO -FAs) have been described as bioactive lipids with anti-inflammatory properties and have been found to inhibit STING activation as a response to virus infections (Figure 8 compounds NO -cLA, 9-NO -OA, and 10-NO -OA) [199,200]."
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"This will further strengthen the inflammatory response.A study by Hansen and colleagues demonstrates the potential of NO -FAs to inhibit STING signaling via adduction to cysteine 88 and 91, as well as the N-terminal histidine (His18)."
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"Furthermore, we show that NO 2 -FAs can inhibit STING signaling and the release of type I IFNs in response to stimulation with the STING agonists, dsDNA and cGAMP, in addition to infection with the DNA virus HSV-2."
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"Additionally, NO 2 -FA treatment of immortalized fibroblasts from SAVI patients led to decreased STING dependent type I IFN responses."
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"NF-κB signaling in lung macrophages may be further truncated via NO -FA inhibition of the STING pathway."
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"As reported by Hansen et al. in 2018, NO -FAs can be formed in response to virus infection and are able to inhibit stimulator of interferon genes (STING) signaling, leading this way to an anti-inflammatory activity against several diseases, such as, systemic lupus erythematosus, Aicardi-Goutiéres syndrome and STING-associated vasculopathy [96]."
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