IndraLab

Statements

Potassium(1+) activates KCNH2. 14 / 14
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"Consistent with previous reports we show that increases in extracellular potassium reduce HERG block by quinidine and cisapride."
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"The modulation of HERG (and IK ~) by [K+] e may have physiologic importance."
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"First, lowering of extracellular potassium directly decreases hERG currents in the heart [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
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"The observation that HERG current inhibition was reduced by 17% in the presence of 10 mM external potassium is significant, given that such an increase in extracellular potassium may be observed in is[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10388757
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"The left panel of XREF_FIG shows whole cell lysate and Western blot of stable HEK-WT HERG cells treated with low potassium media."
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"For example, elevation of [K+] e from 2 to 5 mM increased HERG current by 40%."
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"HERG Current Is Activated by Extracellular K+ The K+ selectivity of HERG was determined by measuring the reversal potential of currents in oocytes bathed in ND96 solution containing different concentr[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"HERG current is K+ selective, declines with depolarizations above 0 mV, is activated by extracellular K+, and is blocked by lanthanum."
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"This elevation in [K+] e would increase the contribution of HERG (IKr) to net repolarizing current."
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"We found that changes in [K+] e over a physiologic range significantly modulated the amplitude of HERG current."
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"Mutations in genes encoding the major potassium ion channels mediating this event, KCNQ1 and HERG, therefore account for ~ 90% of cases of inherited long QT syndrome."
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"Kv11.1 gating and trafficking are modulated by temperature, drugs, and extracellular K+ concentration but experimental characterization of their combined effects is challenging."
36752166
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"HERG channels are paradoxically activated by a modest increase in extracellular potassium concentration."
10760544
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"Modulation of HERG and IK, by [K+], and Blockers Blockers Methanesulfonanilides (IC ~ o) Modulation of Current Current by [K *] ~ La ~- Co2+ E-4031 MK-499 Dofetilide HERGa + + 1 p.Mb 1 pMb ND IK, (gui[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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