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UCHL1 activates ERK. 7 / 7
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"Higher expression of ubiquitin C-terminal hydrolase-L1 (UCHL1) in liver metastasis than in primary tissue could activate the ERK1/2 signaling, thus promoting the proliferation, migration, and invasion of GC cells (55)."
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"UCHL1 activated Akt and Erk1/2, which process also required enzymatic activity and was necessary for mediating cell migration and invasion."
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"In addition, a study demonstrated that upregulation of MDR1, CD147 and MMP can also be achieved via activation of the MAPK/Erk signaling pathway by UCH-L1 (Fig. 5) (86)."
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"UCHL1 activated Akt and Erk1/2, which process also required enzymatic activity and was necessary for mediating cell migration and invasion."
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"These findings demonstrated that UCHL1 promoted cell proliferation, migration, and invasion depending on its de-ubiquitinase activity by activating Akt and Erk1/2, which may account for its higher positive expression rate in liver metastases from gastric cancer."
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"UCHL1 activated Akt and Erk1/2, which process also required enzymatic activity and was necessary for mediating cell migration and invasion."
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reach
"Wang et al (86) transfected MCF7 cells (a highly invasive breast cancer cell line) with a vector carrying UCH-L1; UCH-L1 enhanced the invasive ability of breast cancer by activating the MAPK/Erk signaling pathway."
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