IndraLab

Statements

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"High levels of USP18 in murine hematopoietic cells block the cytokine induced terminal differentiation of monocytic cells (Liu et al., 1999)."
31820845
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"Together, this indicates that USP18 depletion stopped proliferation and induced a commitment switch to myogenic differentiation (Fig. 3G)."
37002195
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"Deficiency of Usp18 reduced Th17 cell differentiation in vitro and in vivo as a result of hyperactivated NF-kappaB and NFAT signaling and increased levels of IL-2."
29685903
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"ISG15 KD did not affect differentiation, and in the double KD, ISG15 KD did not prevent differentiation driven by USP18 depletion (Fig. 4C, D)."
37002195
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"Interestingly, we found that USP18 depletion first enhances differentiation, but was concomitant with dysregulation of myogenic transcription factors."
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"USP18 depletion first stimulated differentiation initiation."
37002195