IndraLab

Statements

TP53 increases the amount of KCNH1. 7 / 7
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"Moreover, the activation of p53 by nutlin-3 induced cell growth arrest in MG-63 cells and reduced Eag protein level, while the inactivation of p53 by pifithrin-alpha (PFT-alpha) promoted MG-63 cell growth and increased Eag protein expression."
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"XREF_BIBR It has been suggested that mutated or inactive p53 increases Eag1 expression; p53 is mutated in most tumors including HCC."
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"On the other hand, the downregulation of h-eag1 expression induced by co-application of p53 activator and miR-34a was abolished by E2F1 overexpression (XREF_FIG)."
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"Furthermore, p53 could modulate the expression of Eag in MG-63 cells as shown by the use of p53 activator and inhibitor."
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"When Eag expression is high, it activates p38 MAPK, which in turn inactivates p53 and relieves the inhibition of Eag expression by p53."
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"Inactivation of p53 activity, as is the case in many cancers, can thus cause oncogenic overexpression of h-eag1 by relieving the negative feed-forward regulation."
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"On the other hand, inactivation of p53 by PFT-alpha promoted cell growth and increased Eag protein expression, which were abrogated by Eag-shRNA (XREF_FIG)."
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