IndraLab

Statements

reach
"The function of OTUD6B in response to viral infection has rarely been reported, except that a recent study found that OTUD6B from zebrafish can negatively regulate the antiviral response by suppressing K63-linked ubiquitination of IRF3 and IRF7 (28)."
37650650
reach
"Over-expression of Otud6b in zebrafish attenuated induction of viral and chemical IFN signaling, whereas loss of otud6b strongly promoted the antiviral response."
35923854
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"Thus, unlike the previous report that zebrafish OTUD6B negatively regulates the antiviral response by suppressing K63-linked ubiquitination of IRF3 and IRF7, we demonstrate that human OTUD6B actually enhances type I IFN response and has the potential for antiviral therapy."
37650650