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USP35 decreases the amount of SLC7A11. 2 / 2
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"Consequently, we found that BRD4 overexpression rescued the decrease in SLC7A11 protein level induced by USP35 knockdown (Fig. 6A)."
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"Furthermore, immunohistochemistry analysis revealed that USP35 increased the levels of SLC7A11, whereas (+)-JQ-1 treatment significantly reduced the levels of SLC7A11, and increased the level of 4-HNE, a marker of ferroptosis, in ER+ breast tumors (Fig. 7F, G)."
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