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PKA inhibits KCNH2. 6 / 6
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"Furthermore, broad-specificity inhibitors of protein kinase A (PKA) or protein kinase C (PKC) failed to stimulate hERG down-regulation in the presence or absence of ouabain (unpublished data), suggesting that glycoside induced down-regulation of hERG is independent of PKA- and PKC dependent phosphorylation."
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"Furthermore, broad-specificity inhibitors of protein kinase A (PKA) or protein kinase C (PKC) failed to stimulate hERG down-regulation in the presence or absence of ouabain (unpublished data), suggesting that glycoside induced down-regulation of hERG is independent of PKA- and PKC dependent phosphorylation."
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"It has been demonstrated in the Xenopus laevis oocyte expression system that PKA can reduce hERG currents via direct phosphorylation of all four putative PKA consensus sites XREF_BIBR."
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"In addition, it may be possible to modulate hERG activity with drugs acting on protein kinases, as hERG current can be reduced by protein kinase A activity [119,120] and further research has teased out an indirect role for protein kinase C in hERG activity [121].4.3 Compounds influencing hERG intracellular sortingOne mechanism for the loss of normal channel function in some familial forms of LQTS is defective protein328Expert Opin."
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"HERG current may be decreased by cAMP dependent activation of PKA; however, a putative direct binding of cAMP to the channel causes opposite effects."
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"However, two independent studies concur, that in rat corticotrope cells K + channels inhibited by PKA and insensitive to tetraethylammonium as well as apamin, such as HERG or TREK-1 are likely to unde[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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