IndraLab

Statements

PKA inhibits KCNH2. 4 / 4
| 4
reach
"It has been demonstrated in the Xenopus laevis oocyte expression system that PKA can reduce hERG currents via direct phosphorylation of all four putative PKA consensus sites XREF_BIBR."
23029432
reach
"Furthermore, broad-specificity inhibitors of protein kinase A (PKA) or protein kinase C (PKC) failed to stimulate hERG down-regulation in the presence or absence of ouabain (unpublished data), suggesting that glycoside induced down-regulation of hERG is independent of PKA- and PKC dependent phosphorylation."
24152733
reach
"Furthermore, broad-specificity inhibitors of protein kinase A (PKA) or protein kinase C (PKC) failed to stimulate hERG down-regulation in the presence or absence of ouabain (unpublished data), suggesting that glycoside induced down-regulation of hERG is independent of PKA- and PKC dependent phosphorylation."
24152733
reach
"HERG current may be decreased by cAMP dependent activation of PKA; however, a putative direct binding of cAMP to the channel causes opposite effects."
23029432