IndraLab

Statements

Mutated ATXN3 inhibits DNA repair. 3 / 3
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"The mutation of Ataxin-3 disrupts the normal processes of DNA repair, leading to neuron loss in CNS, as well as the abnormal activation of non-neuronal cells in brain (Rüb et al., 2002; Yang et al., 2017)."
35846567
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"Expression of polyQ expanded mutant ATXN3 also decreases DNA repair efficiency and enhances vulnerability of cells following irradiation or exposure to genotoxins."
31669734
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"Insights into normal ATXN3 kinetics within the DDR could shed light on how mutant ATXN3 directly or indirectly disrupts DNA repair."
31669734