IndraLab

Statements

CYLD inhibits TLR4. 3 / 3
| 3
reach
"TLR4 engagement in the presence of zVAD-fmk did not lead to MLKL oligomerization in CYLD deficient cells (XREF_FIG), demonstrating that removal of CYLD prevents TLR4 from inducing necroptosis."
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"CYLD also negatively regulates NF-kappaB activation in IL-1R and TLR4 signaling through its DUB activity (Sun, 2010b)."
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"However, the specific CYLD target modulating TLR3 and TLR4 responses remains to be determined XREF_BIBR (Sidebar A)."
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