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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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CYLD inhibits TLR4. 3 / 3

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"TLR4 engagement in the presence of zVAD-fmk did not lead to MLKL oligomerization in CYLD deficient cells (XREF_FIG), demonstrating that removal of CYLD prevents TLR4 from inducing necroptosis."

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"CYLD also negatively regulates NF-kappaB activation in IL-1R and TLR4 signaling through its DUB activity (Sun, 2010b)."

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"However, the specific CYLD target modulating TLR3 and TLR4 responses remains to be determined XREF_BIBR (Sidebar A)."

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CYLD inhibits TLR4. 3 / 3

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