IndraLab

Statements

PARP3 binds BAP1. 4 / 4
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"Several studies and clinical trials [ xref ], have shown that PARP inhibitors influence cancers in which mutations in BRCA1 or BRCA2 are observed, which led us to assume that the cancerous growth-inhibiting interaction of BAP1 with BRCA1 may already be perturbed in this case, and that PARP inhibitors may actually be blocking the novel interaction of BAP1 with PARP3 which enhances cancer growth."
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"Thus, we suspect that the novel interaction of BAP1 and PARP3 may also be perturbed by PARP inhibitors, leading to inhibition of cancer growth."
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"In this scenario, it is possible that the novel interaction of BAP1 with PARP3 in cancerous cells may be promoting cancerous growth, possibly through regulation of DNA repair and apoptosis."
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"Perturbation of the interaction of BAP1 with PARP3 , using PARP3 inhibitors, may then suppress cancerous growth, at least in sarcomatoid MPM."
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