IndraLab

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"Moreover, shikonin suppressed the phosphorylation of p38, inhibitor of kappaB (IkappaB) kinase (IKK)-beta and IkappaB-alpha, and the subsequent IkappaB-alpha degradation induced by PMA+ cAMP; however, the PMA+ cAMP induced phosphorylation of extracellular signal related kinase (ERK), which resulted in minor inhibition and phosphorylation of c-Jun N-terminal kinase (JNK), seemed to be unaffected by shikonin treatment."
21806999
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"While a notable body of literature suggest that HBx interacts with all major forms of NF-kappaB and activates target promoters bearing NF-kappaB, cAMP response element (CRE), and AP-1 consensus motifs; induces the degradation of p105 NF-kappaB1 and IkappaBalpha; or sequesters IkappaBalpha to sustain NF-kappaB activation (Robert Weil Direct Association and nuclear import of the HBx protein with the NF-KB inhibitor) where its activity is enhance by VHL binding protein (VBP1) in a cooperative manner; the mechanism for HBx activation of NF-kappaB remains undefined."
20010875
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"Although transfection studies suggest that PKA increases the activity of NF-kappaB, some reports have indicated that elevation of cAMP reduces NF-kappaB activity, possibly by stabilizing IkappaB-alpha[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
9150141