IndraLab

Statements

USP45 binds CORO1B. 4 / 4
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reach
"USP45 interacted with and deubiquitinated the actin-regulatory protein Coronin 1B (Coro1B) to promote actin turnover."
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"Interestingly, coimmunoprecipitation (co-IP) assays showed that USP45 bound to Coro1B but not Coro1C via its N-terminal seven-bladed β-propeller domain (Fig. 5, A and B; and Fig. S3, A and B)."
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sparser
"Given that a large fraction of USP45 is localized to endosomes and lysosomes, it is likely that the USP45–Coro1B axis imposes strict spatial and temporal control on N-WASP activity within the endo-lysosome system, thereby regulating V-ATPase localization and lysosomal function."
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sparser
"Interestingly, coimmunoprecipitation (co-IP) assays showed that USP45 bound to Coro1B but not Coro1C via its N-terminal seven-bladed β-propeller domain ( xref ; and xref )."
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