IndraLab

Statements

HCN1 activates calcium(2+). 4 / 4
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"Thus, the depolarizing influence of HCN1 channels causes inactivation of T-type Ca 2+ channels, which prevents T-type Ca 2+ channels from driving spontaneous firing, and enables the spike ADP."
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"GABAergic inhibitory interneurons predominantly express HCN1, on which BIL selectively acts to increase their intrinsic excitability and mortality by enhancing HCN1 activity and Ca 2+ -dependent membrane targeting."
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"HCN1 channels inhibit mEPSC frequency by limiting T-type Ca 2+ channel activity."
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"These results indicate that HCN1 blockade reduces Ca influx into the PV+ IN presynaptic boutons.The effect of ZD7288 could result from a reduction in the size of the Ca transient elicited by a single action potential or a decrease in the number of action potentials that invade the presynaptic bouton in response to the brief train of electrical stimulation."
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