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OTUD7B deubiquitinates SOX2. 2 / 2
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"It was previously reported that Otud7b is a deubiquitinase that deubiquitinates and stabilizes Sox2 and promotes the maintenance of neural progenitor cells.61 Otud7b silencing decreases Sox2 levels and promotes neuronal differentiation in cultured cells."
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"COP1, as the substrate receptor, interacts directly with and ubiquitylates <span class="match term1">Sox2</span>, while <span class="match term0">OTUD7B</span> removes polyUb conjugates from <span class="match term1">Sox2</span> and increases its stability"
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