A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

EGFR affects EGF
| 4
EGF binds mutated EGFR. 4 / 4
| 4
reach
"A mutant EGF receptor devoid of intrinsic protein-tyrosine kinase activity bound EGF and dimerized normally yet failed to undergo ligand induced internalization."
reach
"EGF and transforming growth factor-a (TGF-a) bound to the mutant EGFR with high affinity and enhanced the intrinsic mutant EGFR kinase activity."
reach
"Mutant EGFR with the deletion of the dimerization loop weakly bind to EGF, but fails to be phosphorylated [XREF_BIBR]."
reach
"This can be justified if both the EGF and MOI bind to the bound mutant EGFR independently at separate locations, which explains the presence of excess biotin in the second interaction."
EGF affects EGFR
| 4
EGF binds mutated EGFR. 4 / 4
| 4
reach
"A mutant EGF receptor devoid of intrinsic protein-tyrosine kinase activity bound EGF and dimerized normally yet failed to undergo ligand induced internalization."
reach
"EGF and transforming growth factor-a (TGF-a) bound to the mutant EGFR with high affinity and enhanced the intrinsic mutant EGFR kinase activity."
reach
"Mutant EGFR with the deletion of the dimerization loop weakly bind to EGF, but fails to be phosphorylated [XREF_BIBR]."
reach
"This can be justified if both the EGF and MOI bind to the bound mutant EGFR independently at separate locations, which explains the presence of excess biotin in the second interaction."