IndraLab

Statements

EGF binds mutated EGFR. 4 / 4
| 4
reach
"EGF and transforming growth factor-a (TGF-a) bound to the mutant EGFR with high affinity and enhanced the intrinsic mutant EGFR kinase activity."
1678600
reach
"Mutant EGFR with the deletion of the dimerization loop weakly bind to EGF, but fails to be phosphorylated [XREF_BIBR]."
27463710
reach
"A mutant EGF receptor devoid of intrinsic protein-tyrosine kinase activity bound EGF and dimerized normally yet failed to undergo ligand induced internalization."
2449972
reach
"This can be justified if both the EGF and MOI bind to the bound mutant EGFR independently at separate locations, which explains the presence of excess biotin in the second interaction."
28611939