IndraLab

Statements

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"Likewise, ubiquitin-specific peptidase 2 (USP2) downregulates the NF-κB pathway, inhibiting EMT in clear cell renal cell carcinoma metastasis (Duan et al., 2022)."
39901876
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"For example, USP2 and USP7 modulate p53 and MDM2, impacting cell survival and tumor development, while USP22 stabilizes c-Myc, driving cancer proliferation and metastasis [9–13]."
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"USP2 overexpression promoted proliferation and metastasis, and induced the EMT in CM cells in vitro, while specific inhibition of USP2 by ML364 produced the opposite effects."
37199836
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"USP2 promotes cell proliferation and metastasis in choroidal melanoma via stabilizing Snail ."
37199836
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"Thus, USP2 appears to be an attractive anticancer target, and indeed, small-molecule inhibitors of USP2 have shown to inhibit growth and metastasis of cancer cells (22, 40)."
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"USP2 promotes cell proliferation and metastasis in choroidal melanoma via stabilizing Snail."
37199836