IndraLab

Statements

Mutated ATXN3 decreases the amount of PRKN. 3 / 3
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"Interestingly, expression of mutant ataxin-3 in the brains of SCA3 mice decreases the levels of CHIP and parkin [62,63] ."
31079890
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"Mutant Ataxin-3, which polyglutamine expansion is associated with the onset of Machado-Joseph neurodegenerative disease, promotes the degradation of Parkin via autophagy and leads to decreased Parkin levels in vivo [XREF_BIBR, XREF_BIBR]."
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"Intriguingly, the presence of the mutant ataxin-3 also causes a reduction in parkin levels in the brains of MJD transgenic mice."
23653622