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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Mutated ATXN3 decreases the amount of PRKN. 2 / 2

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"Intriguingly, the presence of the mutant ataxin-3 also causes a reduction in parkin levels in the brains of MJD transgenic mice."

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"Mutant Ataxin-3, which polyglutamine expansion is associated with the onset of Machado-Joseph neurodegenerative disease, promotes the degradation of Parkin via autophagy and leads to decreased Parkin levels in vivo [XREF_BIBR, XREF_BIBR]."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...