IndraLab

Statements

PRKD1 phosphorylates USP28. 4 / 4
| 4
rlimsp
"(A) Multiple sequence alignment of the two putative PRKD1 phosphorylation sites in USP28."
24623306
rlimsp
"We further showed that PRKD1 phosphorylates USP28, which interacts with and stabilizes ZNF304 from proteolytic degradation."
24623306
rlimsp
"Notably, USP28 contains two predicted phosphorylation sites for PRKD1 (consensus sequence LxRxxS, [Nishikawa et al., 1997]; Figure 5A), a serine/threonine protein kinase (Johannes et al., 1994) isolated in our RNAi screen (Figure 2—figure supplement 1) that is dysregulated in a variety of cancers (Sundram et al., 2011)."
24623306
rlimsp
"Figure 5J shows that PRKD1 could phosphorylate a USP28 peptide containing the second, more conserved predicted phosphorylation site (Figure 5A)."
24623306