IndraLab

Statements

KCNMA1 binds PA. 4 / 4
| 4
sparser
"To explore the potential sites of interaction of PAX with the BK channel, we undertook a computational analysis of the interaction of PAX with the BK channel pore gate domain guided by recently available liganded (open) and metal-free (closed) Aplysia BK channel structures."
31879339
sparser
"Moreover, also the mechanism by which PAX binds to the BK channel has been well characterized as inversely related to the open probability (Po) of the BK channel and completely reversible when applied from the internal side in excised-patch experiments [ xref ]."
30126198
sparser
"BK inhibition by PAX is best characterized by the idea that PAX gains access to the channel through the central cavity of the BK channel, and that only a single PAX molecule can interact with the BK channel at a time."
31879339
sparser
"The PAX-BK channel interaction observed in our experiments could probably be affected by the presence of the auxiliary β4 subunit, which could modify channel properties, such as its kon and koff kinetics and the pharmacological features."
30126198