IndraLab

Statements

COPS6 decreases the amount of FBXW7. 3 / 3
| 3
reach
"It is important to point out that CSN6 interacted with all the three isoforms of Fbxw7 XREF_BIBR, XREF_BIBR and reduced the steady-state expression of Fbxw7 in a dose dependent manner (XREF_SUPPLEMENTARY)."
25395170
reach
"These data suggest that CSN6 decreases FBXW7β protein level through ubiquitination regulation in order to prevent FBXW7β-mediated FASN degradation.FBXW7, including FBXW7β, is rapidly degraded by an autoubiquitination mechanism."
37202390
reach
"Compared with wt CSN6, which clearly decreased Fbxw7 expression and increased Myc expression in U2OS cells, the MPN-KQV CSN6 mutant lost these functions (XREF_SUPPLEMENTARY)."
25395170