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COPS6 decreases the amount of FBXW7. 2 / 2

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"Compared with wt CSN6, which clearly decreased Fbxw7 expression and increased Myc expression in U2OS cells, the MPN-KQV CSN6 mutant lost these functions (XREF_SUPPLEMENTARY)."

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"It is important to point out that CSN6 interacted with all the three isoforms of Fbxw7 XREF_BIBR, XREF_BIBR and reduced the steady-state expression of Fbxw7 in a dose dependent manner (XREF_SUPPLEMENTARY)."

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IndraLab

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COPS6 decreases the amount of FBXW7. 2 / 2

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