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Quercetin inhibits NLRP3. 94 / 94
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"A study showed that quercetin can regulate oxidative stress to improve inflammation and protect against RF.68 Ma discovered that quercetin inhibited the activation of NLRP3 inflammatory vesicles to improve tubulointerstitial transformation and RF.69 Therefore, quercetin may effectively treat kidney diseases."
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"These results suggest that quercetin reduces ExoS and further affects the NLRP3, NLRC4 and caspase-1 pathways."
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"The purpose of the present study was then to determine if the NLRP3 inflammasome was activated with the exacerbated production of IL-1beta and IL-18 in the kidney of STZ induced diabetic rats associated with high urate level and lipid metabolism abnormality, and conversely, if quercetin and allopurinol inhibited renal NLRP3 inflammasome activation involved in their actions on hyperuricemia and lipid metabolism disorder in this model."
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"Quercetin suppresses NLRP3 inflammasome activation in epithelial cells triggered by Escherichia coli O157 : H7."
31564166
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"Furthermore, quercetin and allopurinol were found to suppress renal NLRP3 inflammasome activation, at least partly, via their anti-hyperuricemic and anti-dyslipidemic effects, resulting in the amelioration of STZ induced the superimposed nephrotoxicity in rats."
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"NLRP3 inflammasome inhibition by quercetin is independent of autophagy."
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"Since quercetin inhibited both the NLRP3 and AIM2 inflammasome, but not the NLRC4 inflammasome, we hypothesized that quercetin inhibition might be through the adaptor protein ASC."
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"Quercetin and allopurinol were firstly confirmed to suppress renal NLRP3 inflammasome activation characterized by down-regulation of the NLRP3 and therefore reduction of Caspase 1 in STZ treated rats."
22701621
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"Quercetin inhibits constitutively active NLRP3 inflammasome."
28148962
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"As shown in Fig. 4 H, both NAC and quercetin significantly attenuated the upregulation of NLRP3 and cleaved-caspase1."
34688696
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"Quercetin inhibits NLRP3 and AIM2 inflammasome activation."
28148962
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"Since quercetin was able to inhibit both the NLRP3 and AIM2 inflammasomes, we investigated if this flavonoid could also inhibit the NLRC4 inflammasome."
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"Quercetin suppresses TNF/TNFR and NLRP3 downstream signals, such as Nf-κB and IL-1β (Li et al., 2016)."
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"Quercetin significantly inhibited BCRD-induced neuron pyroptosis via downregulation of PYD and card domain containing (ASC), NLR family pyrin domain containing 3 (NLRP3), and caspase-1, and quercetin could reverse BCRD-caused inhibition of neuron viability."
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"We found that both ATP and nigericin (inducers of mitochondrial dysfunction and K + efflux), as well as alum (lysosomal damage) induced NLRP3 inflammasome activation were inhibited by quercetin."
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"Notably, lifestyle interventions like aerobic exercise and dietary supplements, including vitamin D, quercetin, and baicalin, also reduce vascular inflammation via NLRP3 pathways [217,226,227,228,229], emphasizing the importance of integrative approaches in managing this condition.In summary, these preclinical models shed light on key mechanisms, including harmful processes such as oxidative stress, inflammation, and NLRP3 inflammasome activation, as well as protective pathways like the nitrate-nitrite-NO cascade and the SIRT1-eNOS axis."
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"Quercetin inhibited the activation of NLRP3 inflammasome, reducing lactate production and lung pro-inflammatory factor release and ameliorating lung tissue injury, thus attenuating septic lung injury in mice.47 Quercetin in the Treatment of Radiological Lung Injury."
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"Corrigendum: Quercetin suppresses ovariectomy-induced osteoporosis in rat mandibles by regulating autophagy and the NLRP3 pathway."
38826627
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"Quercetin suppresses the NLRP3 inflammasome by affecting these regulators [86]."
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"Additionally, it has been previously observed that quercetin successfully inhibited Nod-like receptor family pyrin domain-containing 3 (NLRP3) of the inflammasome family [29]."
36364256
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"They found that quercetin treatment dramatically suppressed the upregulation of NLRP3, C-terminal caspase recruitment domain, and pro-caspase-1 in the knee joints after MSU injection."
35959909
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"Combined quercetin and simvastatin attenuate hepatic fibrosis in rats by modulating SphK1/NLRP3 pathways."
38128755
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"However, the beneficial effects were reversed by EX527 suggesting that the inhibition of quercetin on apoptosis was SIRT1 dependent.In summary, the present study suggested that quercetin protected aga[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"To prevent the inflammatory response from persistently exacerbating the development of OA, Li et al. suggested that quercetin inhibits IL-1β-induced inflammation and cartilage degradation by suppressing the NLRP3 signaling pathway."
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"Similarly, quercetin also inhibited cholesterol crystal induced NLRP3 inflammasome activation."
28148962
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"NIH-3T3 cells were treated with quercetin or MCC950 (a specific inhibitor of NLRP3) before stimulation with lipopolysaccharide (LPS) and ATP to induce cell pyroptosis."
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"As discussed previously, the inhibition of NLRP3 activation is regulated by ROS and TXNIP, and quercetin has been reported to act as a potent antioxidant and hence inhibits the NLRP3 activation [207, 208]."
36006570
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"Quercetin can inhibit the activation of NLRP3 inflammasomes."
36506811
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"Similarly, quercetin has been shown to prevent NLRP3 inflammasome in HCT116 and HT29 colon cancer cells and a nude-mouse xenograft model [140]."
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"The results indicated that NAC and quercetin diminished the increase of NLRP3 compounds."
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"Quercetin inhibits the nuclear accumulation of PKM2, upregulates SIRT1, inhibits the activation of NLRP3 inflammasomes and reduces the release of pyroptosis-related cytokines (IL-1β, IL-18 and HMGB1) in macrophages (92)."
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"Quercetin inhibits the protein expressions of NLRP3 inflammasome pathway to decrease pro-inflammatory cytokine expressions as curcumin does [78], and the docking results confirmed quercetin forms hydrogen bonds within the ATP binding sites of p38/MAPK at Lys53, Thr106, His107, Met109, Asp112, and Asp168 residues; and binding with the ATP binding pocket of JNK2 at Glu109, Met111."
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"Previous researches indicate that quercetin, ginsenoside, and kaempferol extracted from TCM herbs can effectively inhibit the activation of NLRP3 inflammasomes ( Chen et al., 2022 ; Jiang et al., 2022[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Quercetin suppresses the NLRP3 inflammasome by affecting these regulators."
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"Moreover , quercetin reduced the NLRP3 expression and inhibited the P. aeruginosa-mediated cleavage of caspase-1 as well as mature IL-1beta ."
32817626
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"Not only the components of MAPK pathway , quercetin also suppressed the NLRP3 expression and inhibited the P. aeruginosa-mediated cleavage of caspase-1 ( Fig 6 ) ."
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"In aged mice, quercetin was reported to attenuate neuroinflammation by modulating the SIRT1/NLRP3 pathway (83)."
35935939
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"In particular, quercetin, the most abundant compounds in SME could contribute to reduce NLRP3 inflammasome and inflammatory cytokines in hippocampus and skeletal muscle, respectively."
38030047
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"Additionally, quercetin, a natural flavonoid, has been shown to prevent neuronal damage by promoting mitophagy and suppressing the activation of NLRP3 inflammatory corpuscles mediated by mitochondrial ROS in microglia, offering a potential innovative therapeutic approach for diseases related to neuroinflammation [204]."
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"Quercetin was able to restrict the production of NLRP3 inflammasome components such as NLRP3, ASC and caspase-1 and coordinate various inflammasome regulators (e.g., NRF2, SIRT1 and TXNIP) (87)."
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"Importantly, rescue experiments confirmed that quercetin inhibited IL-1beta-induced rat chondrocyte injuries in vitro by suppressing the IRAK1/NLRP3 signaling pathway."
34295174
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"Quercetin administration significantly decreased reactive oxygen species production, inhibited NLRP3 inflammasome activation and reduced inflammatory cytokine levels."
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"In a study, using streptozotocin- (STZ-) induced diabetic nephropathy rat model leading to hyperuricemia and dyslipidemia, quercetin was found to block NLRP3 inflammasome activation [XREF_BIBR]."
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"The current study proved for the first time that quercetin treatment remarkably inhibited hypothalamic NLRP3 and caspase-1 in high fructose fed rats, being consistent with the reduction of hypothalami[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"As its action mechanisms, quercetin directly inhibits the coronavirus major protease [ xref , xref ] and the inflammasome NLR family pyrin domain containing 3 (NLRP3) in macrophages [ xref ]."
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"Immunohistochemical staining showed that quercetin significantly decreased the numbers of NLRP3 (Figure 1F) and Caspase 3 (Figure 1G) positive cells in rat articular cartilage when compared with the OA group."
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"Together, these results suggest that the inhibition of hypothalamic AMPK and TXNIP dysregulation and NF-kappaB pathway and NLRP3 inflammasome activation by quercetin may reduce hypothalamic inflammati[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Quercetin by affecting this inflammasome successfully suppressed NLRP3 and thus acts as a potential treatment for severe inflammation and in life-threatening conditions like COVID-19 [47]."
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"Quercetin Inhibited IL-1beta-Induced Rat Chondrocyte Injuries in vitro by Suppressing the IRAK1/NLRP3 Signaling Pathway."
34295174
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"These results suggested that quercetin could inhibit inflammation and chondrocyte apoptosis by suppressing IRAK1/NLRP3 signaling in IL-1β‐treated chondrocytes."
34295174
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"Quercetin has been shown to suppress the activation of the NLRP3 inflammasome, which may contribute to its neuroprotective effects [74]."
37047299
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"Interestingly, AMPK agonists counteract this beneficial effect by weakening quercetin’s inhibition of NLRP3 inflammasome activity [34]."
38927103
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"Quercetin has been shown to inhibit PM -induced inflammation by inhibiting the activation of NF-kB and NLRP3 inflammasome through the AMPK signaling pathway [87]."
37047299
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"Quercetin and other GBE constituents block the activation of NLRP3 inflammasome and Th17, thus reducing hyperinflammation and hypercytokinemia states."
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"Quercetin, luteolin and apigenin suppressed NLRP3 induction and/or caspase-1 activation in human umbilical vein endothelial cells, colitis model in mice and kidney injury model in rats ( Marquez-Flore[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Quercetin , through autophagy induction , also inhibits NLRP3 activation while protecting mitochondrial integrity and inhibiting ROS production , upon bacterial infection in vitro [ 193 ] ."
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"Importantly, it has been shown that quercetin inhibits the coronavirus major protease [61] and NLRP3 inflammasome [62]."
34966165
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"Quercetin Inhibits NF-kappaB and NLRP3 Inflammasome in Stroke and PM 2.5 by AMPK Signaling Pathway."
37047299
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"Based on this evidence, we speculated that quercetin might help to prevent IL-1β-induced rat chondrocyte injuries in vitro by suppressing the IRAK1/NLRP3 signaling pathway."
34295174
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"Quercetin has been shown to inhibit the activation of NF-kB and NLRP3 inflammasome by activating the AMPK signaling pathway, which may have potential therapeutic implications for stroke [60]."
37047299
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"It has been found that quercetin (QC) prevents neuronal damage by inhibiting the NLRP3 pathway (Lin et al., 2022), but factors such as its low solubility and poor stability limit its effectiveness."
38817551
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"Other studies have indicated that quercetin inhibits the activation step of the NLRP3 inflammasome by interfering with ASC-speck oligomerization, which may explain why it cannot inhibit NLRC4 since ASC is dispensable for NLRC4 activation (Domiciano et al., 2017)."
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"Quercetin suppresses NLRP3 inflammasome activation in epithelial cells triggered by Escherichia coli O157 : H7."
28476502
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"Recent studies [XREF_BIBR, XREF_BIBR] have demonstrated that quercetin could impair NLRP3 inflammasome activation to improve renal inflammation."
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"For example, in streptozotocin-diabetic rats, the use of quercetin and allopurinol for 7 weeks inhibits the activation of NLRP3, PPARa, and up-regulation of sterol regulatory element-binding protein-1c (SREBP-1c) by TXNIP down-regulation in the liver, showing less hepatic lipid accumulation [190]."
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"Our data indicated that quercetin and aspirin effectively downregulated caspase-1, NLRP3, apoptosis-associated speck-like protein containing a caspase recruitment domain, and pro-caspase-1 (Fig. 5A–G) on both mRNA and protein levels."
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"Quercetin was also reported to prevent E. coli adhesion to epithelial cells by suppressing focal adhesions and inactivation of NLRP3 in Caco2 cells [164,165]."
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"Quercetin was also shown to synergize with aspirin to inhibit the NLRP3 inflammasome, which is a potential underlying mechanism in its anti-inflammatory effects."
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"We found that quercetin can also attenuate TNF-α, IL-1β, iNOS, and NLRP3, which was in line with previous research.It has also been reported that IL-1β signaling is significantly involved in the patho[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Quercetin and salvianolic acid A also inhibited the NLRP3 inflammasome, and the mechanism of salvianolic acid A was mainly based on the TXNIP/NLRP3 and TXNIP/ChREBP pathways (130, 131)."
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"In addition, quercetin can suppress NLRP3 inflammasome directly."
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"Quercetin suppresses NLRP3 inflammasome activation and attenuates histopathology in a rat model of spinal cord injury."
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"In addition, quercetin could inhibit the NF-κB production of NLRP3 inflammasomes and IL-1β and inhibit the inflammatory response by interfering with the NF-κB pathway."
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"We used glyburide to inhibit NLRP3 inflammasome [34] and, allopurinol and quercetin to inhibit uric acid and triglyceride synthesis [ 35 , 36 ]."
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"Studies have illustrated quercetin’s ability to inhibit the NLRP3 inflammasome pathway in THP-1 macrophages, reducing the maturation of N-terminal gasdermin-D (N-GSDMD) and IL-1β in a concentration-dependent manner (Luo et al., 2022)."
38855739
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"Quercetin suppresses the NLRP3 inflammasome by affecting these regulators."
| PMC
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"Quercetin inhibits NLRP3 inflammasome by affecting TXNIP."
| PMC
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"Saeedi-Boroujeni and Mahmoudian-Sani (2021) showed that, the antioxidant properties of quercetin can inhibit NLRP3 inflammasome activity via thioredoxin-interacting protein (TXNIP) inhibition and increasing the expression of Sirtuin 1 (SIRT1) thus preventing the exacerbation of inflammation."
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"In addition, quercetin has been shown to suppress NLRP3 inflammasome activation in a mouse vasculitis model [XREF_BIBR] and a rat model of spinal cord injury [XREF_BIBR] as well as ameliorate kidney injury in streptozotocin induced rats [XREF_BIBR]."
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"By promoting mitosis, quercetin reduces ROS accumulation and relieves NLRP3 inflammation activation and IL-1β production [7]."
37110714
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"The findings showed that the quercetin could prevent NLRP3 inflammasome activation in E. coli O157 : H7 infection by maintaining the mitochondrial membrane integrity and inhibiting mitochondrial ROS release to cytosol."
| PMC
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"We observed that AIM2 and NLRP3 were up-regulated after hepatic IRI, while quercetin effectively inhibited the activation of AIM2 and NLRP3."
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"With the same disease model, administration of quercetin at 150 mg/kg for 2 weeks counteracted arthritis by restoring the Th17 and Treg balance, inhibited NLRP3 inflammasome activation and triggered an HO1 mediated inhibitory effect on inflammatory cytokines and mediators (Yang et al. 2018)."
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"The results showed that quercetin was able to inhibit the activation of NLRP3 and AIM2 inflammasomes, but not NLRC4 inflammasome."
| PMC
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"Quercetin, through autophagy induction, also inhibits NLRP3 activation while protecting mitochondrial integrity and inhibiting ROS production, upon bacterial infection in vitro [XREF_BIBR]."
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"Moreover, the inhibition of resistin-induced NLRP3 by MCC950 or quercetin could enhance the sensitivity of anticancer drugs in CRC."
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"For example, quercetin, luteolin, and epigallocatechin gallate inhibit TXNIP/NLRP3 by reducing ROS in ECs (Wu et al., 2014)."
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"Overall, we suggested that quercetin could inhibit NLRP3/ AIM2-induced macrophage pyroptosis."
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"Similarly , quercetin was able to inhibit NLRP3 activation by interfering with ASC oligomerization and prevented IL-1beta secretion in macrophages [ 41 ] ."
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"Quercetin suppresses ovariectomy-induced osteoporosis in rat mandibles by regulating autophagy and the NLRP3 pathway."
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"In db/db mice, 70 mg/kg/day of quercetin significantly reduced NLR family pyrin domain containing 3 (NLRP3) inflammasome formation in the brain by 2.7‐fold (p < 0.01) [59]."
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"The results of this study showed that quercetin and ascorbic acid owing to their antioxidant properties can prevent the activation of NLRP3 inflammasome through TXNIP and thus prevent the exacerbation of inflammation [XREF_BIBR]."
| PMC
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"Other studies have also reported that the quercetin prevents the NLRP3 inflammasome activation through TXNIP."
| PMC
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"In addition, the quercetin, as expected, was also able to inhibit the proinflammatory cytokine production and the NLRP3 inflammasome activation in these rats."
| PMC