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Quercetin inhibits NLRP3. 43 / 43
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"Importantly, it has been shown that quercetin inhibits the coronavirus major protease [61] and NLRP3 inflammasome [62]."
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"Not only the components of MAPK pathway , quercetin also suppressed the NLRP3 expression and inhibited the P. aeruginosa-mediated cleavage of caspase-1 ( Fig 6 ) ."
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"NLRP3 inflammasome inhibition by quercetin is independent of autophagy."
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"In addition, quercetin can suppress NLRP3 inflammasome directly.13Quercetin and its derivatives are being evaluated in five RCTs, including four in hospitalized patients."
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"Recent studies [XREF_BIBR, XREF_BIBR] have demonstrated that quercetin could impair NLRP3 inflammasome activation to improve renal inflammation."
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"Quercetin, through autophagy induction, also inhibits NLRP3 activation while protecting mitochondrial integrity and inhibiting ROS production, upon bacterial infection in vitro [193]."
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"Inhibition of NLRP3 by Fermented Quercetin Decreases Resistin-Induced Chemoresistance to 5-Fluorouracil in Human Colorectal Cancer Cells."
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"Similarly , quercetin was able to inhibit NLRP3 activation by interfering with ASC oligomerization and prevented IL-1beta secretion in macrophages [ 41 ] ."
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"The current study proved for the first time that quercetin treatment remarkably inhibited hypothalamic NLRP3 and caspase-1 in high fructose fed rats, being consistent with the reduction of hypothalami[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Quercetin by affecting this inflammasome successfully suppressed NLRP3 and thus acts as a potential treatment for severe inflammation and in life-threatening conditions like COVID-19 [47]."
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"As its action mechanisms, quercetin directly inhibits the coronavirus major protease [131,132] and the inflammasome NLR family pyrin domain containing 3 (NLRP3) in macrophages [133]."
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"Quercetin suppresses the NLRP3 inflammasome by affecting these regulators."
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"Together, these results suggest that the inhibition of hypothalamic AMPK and TXNIP dysregulation and NF-kappaB pathway and NLRP3 inflammasome activation by quercetin may reduce hypothalamic inflammati[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Quercetin inhibits NLRP3 and AIM2 inflammasome activation."
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"In addition, quercetin has been shown to suppress NLRP3 inflammasome activation in a mouse vasculitis model [XREF_BIBR] and a rat model of spinal cord injury [XREF_BIBR] as well as ameliorate kidney injury in streptozotocin induced rats [XREF_BIBR]."
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"Quercetin suppresses TNF/TNFR and NLRP3 downstream signals, such as Nf-κB and IL-1β (Li et al., 2016)."
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"Quercetin suppresses NLRP3 inflammasome activation and attenuates histopathology in a rat model of spinal cord injury."
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"In addition, quercetin can suppress NLRP3 inflammasome directly."
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"Quercetin, through autophagy induction, also inhibits NLRP3 activation while protecting mitochondrial integrity and inhibiting ROS production, upon bacterial infection in vitro [XREF_BIBR]."
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"Furthermore, quercetin can diminish reactive oxygen species and inhibit NLRP3 inflammasome."
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"Since quercetin was able to inhibit both the NLRP3 and AIM2 inflammasomes, we investigated if this flavonoid could also inhibit the NLRC4 inflammasome."
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"The results showed that quercetin was able to inhibit the activation of NLRP3 and AIM2 inflammasomes, but not NLRC4 inflammasome."
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"Quercetin administration significantly decreased reactive oxygen species production, inhibited NLRP3 inflammasome activation and reduced inflammatory cytokine levels."
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"In a study, using streptozotocin- (STZ-) induced diabetic nephropathy rat model leading to hyperuricemia and dyslipidemia, quercetin was found to block NLRP3 inflammasome activation [XREF_BIBR]."
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"We found that both ATP and nigericin (inducers of mitochondrial dysfunction and K + efflux), as well as alum (lysosomal damage) induced NLRP3 inflammasome activation were inhibited by quercetin."
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"Quercetin and allopurinol were firstly confirmed to suppress renal NLRP3 inflammasome activation characterized by down-regulation of the NLRP3 and therefore reduction of Caspase 1 in STZ treated rats."
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"The findings showed that the quercetin could prevent NLRP3 inflammasome activation in E. coli O157 : H7 infection by maintaining the mitochondrial membrane integrity and inhibiting mitochondrial ROS release to cytosol."
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"The results of this study showed that quercetin and ascorbic acid owing to their antioxidant properties can prevent the activation of NLRP3 inflammasome through TXNIP and thus prevent the exacerbation of inflammation [XREF_BIBR]."
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"In addition, the quercetin, as expected, was also able to inhibit the proinflammatory cytokine production and the NLRP3 inflammasome activation in these rats."
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"Quercetin , through autophagy induction , also inhibits NLRP3 activation while protecting mitochondrial integrity and inhibiting ROS production , upon bacterial infection in vitro [ 193 ] ."
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"Moreover , quercetin reduced the NLRP3 expression and inhibited the P. aeruginosa-mediated cleavage of caspase-1 as well as mature IL-1beta ."
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"The purpose of the present study was then to determine if the NLRP3 inflammasome was activated with the exacerbated production of IL-1beta and IL-18 in the kidney of STZ induced diabetic rats associated with high urate level and lipid metabolism abnormality, and conversely, if quercetin and allopurinol inhibited renal NLRP3 inflammasome activation involved in their actions on hyperuricemia and lipid metabolism disorder in this model."
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"Quercetin suppresses the NLRP3 inflammasome by affecting these regulators."
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"Quercetin inhibits constitutively active NLRP3 inflammasome."
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"Similarly, quercetin also inhibited cholesterol crystal induced NLRP3 inflammasome activation."
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"Quercetin significantly inhibited BCRD-induced neuron pyroptosis via downregulation of PYD and card domain containing (ASC), NLR family pyrin domain containing 3 (NLRP3), and caspase-1, and quercetin could reverse BCRD-caused inhibition of neuron viability."
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"Since quercetin inhibited both the NLRP3 and AIM2 inflammasome, but not the NLRC4 inflammasome, we hypothesized that quercetin inhibition might be through the adaptor protein ASC."
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"For example, in streptozotocin-diabetic rats, the use of quercetin and allopurinol for 7 weeks inhibits the activation of NLRP3, PPARa, and up-regulation of sterol regulatory element-binding protein-1c (SREBP-1c) by TXNIP down-regulation in the liver, showing less hepatic lipid accumulation [190]."
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"Quercetin inhibits NLRP3 inflammasome by affecting TXNIP."
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"Other studies have also reported that the quercetin prevents the NLRP3 inflammasome activation through TXNIP."
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"Quercetin suppresses NLRP3 inflammasome activation in epithelial cells triggered by Escherichia coli O157 : H7."
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"Quercetin attenuates NLRP3 inflammasome activation and apoptosis to protect INH induced liver injury via regulating SIRT1 pathway."
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"Furthermore, quercetin and allopurinol were found to suppress renal NLRP3 inflammasome activation, at least partly, via their anti-hyperuricemic and anti-dyslipidemic effects, resulting in the amelioration of STZ induced the superimposed nephrotoxicity in rats."
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