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AKT1 phosphorylates MTOR. 31 / 33
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"Western blot analysis was applied to measure the levels of NLRC5, microtubule-associated protein 1A/1B-light chain 3 type I (LC3I), LC3II, sequestosome 1 (p62), protein kinase B (AKT), phosphorylated Akt (pAKT), mammalian target of rapamycin (mTOR) and phosphorylated mTOR (pmTOR)."
34802165
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"Interestingly, we found the active form of MTOR, phospho-(Ser2448)-MTOR, at the base of primary cilia in wild-type MEFs ( xref ) making it likely that phospho-(Ser473)-AKT1 phosphorylates MTOR at primary cilia."
29372668
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"Furthermore, upstream overexpression or knockdown of Akt2 or Akt2 phosphorylation inhibition, rather than Akt1 or Akt3, resulted in striking hyperphosphorylation or dephosphorylation of mTOR, p70S6K and rpS6 (all P < 0.05), without any change in total proteins expressions."
26490682
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"Among various cellular functions, activated AKT-1 can phosphorylate mammalian target of rapamycin (mTOR), which regulates cell proliferation by phosphorylation of p70S6 in the G1/S phase transition of[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22445095
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"Additionally, protein kinase B (Akt), phosphorylated Akt (p-Akt), mammalian target of rapamycin (mTOR), and phosphorylated mTOR (p-mTOR) potentially contribute to necroptosis."
38636634
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"Primary antibodies, purchased from CST (Danvers, MA, USA), were as follows: P62, Beclin-1, LC3, phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K), protein kinase B (AKT), phosphorylated AKT ( p -A[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31678171
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"Protein synthesis in skeletal muscle is mainly regulated by the PI3K–AKT ‘phosphoinositide‐3‐kinase’–‘AKT’ [‘protein kinase B’ (PKB)] pathway downstream of anabolic hormones phosphorylating mTORC (‘mammalian target of rapamycin complex’) and its downstream targets, leading to protein translation (Figure 2)."
36760077
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"Akt1 can phosphorylate mTOR ( xref ), which can then in turn trigger phosphorylation of S6 protein for its activation."
19041640
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"Furthermore, AKT1 can directly induce GC resistance by phosphorylating GRs [127] , and AKT1-dependent mTOR phosphorylation increases the expression of the myeloid leukemia cell-1 protein, leading to d[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27643454
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"Phosphorylation of mTOR can subsequently be stimulated by the phosphoinositide-3 kinase (PI3K)-mediated activation of protein kinase B (Akt) XREF_BIBR, XREF_BIBR."
29410403
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"However, recent studies showed that Hsp70 that is induced by the stress response can also inhibit autophagy by activating the RAC-alpha serine/threonine-protein kinase (Akt), which in turn phosphorylates and stimulates mTOR."
37895406
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"Despite modulation of PRAS40, which regulates the mTOR containing TORC1 complex, mutational activation of PIK3CA or AKT1 did not consistently increase phosphorylation of mTOR at serine 2448 or phosphorylation of mTOR target proteins and their targets, including p70-ribosomal protein S6-kinase (p70S6K), eukaryotic elongation factor 4 binding protein 1 (EIF4EBP1), and ribosomal protein S6."
23888070
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"Furthermore, we found the phosphorylation of mammalian target of rapamycin (mTOR), protein kinase B (AKT) and extracellular signal-regulated kinase (ERK), as well as activation of rat sarcoma virus (RAS) were all reduced dramatically after AT treatment in vitro."
34825359
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"Most notably, protein kinase B (AKT) can phosphorylate the mTOR complex 1 (mTORC1)."
36516891
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"AKT1 phosphorylates and activates mTOR."
37048445
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"The phosphoinositide-3 kinase (PI3K)-mediated activation of protein kinase B (Akt) can subsequently stimulate phosphorylation of mTOR [23,24] ."
26454217
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"In Figures XREF_FIG, application of the phosphoinositide 3-kinase (PI 3-K) inhibitor LY294002 (10 muM) during treatment with either EPO (10 ng/ml) or Wnt1 (100 ng/ml) prevented EPO or Wnt1 from phosphorylating mTOR and p70S6K, illustrating that the PI 3-K and Akt1 pathways are necessary for EPO or Wnt1 to phosphorylate mTOR and p70S6K."
22388478
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"We have investigated the effects of insulin, amino acids, and the degree of muscle loading on the phosphorylation of Ser (2448), a site in the mammalian target of rapamycin (mTOR) phosphorylated by protein kinase B (PKB) in vitro."
11884412
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"Primary antibodies included glucose transpoter-4, focal adhesion kinase, PGC-1alpha (Santa Cruz Biotechnology), total protein kinase B (AKT), phosphorylated AKT, total mammalian target of rapamycin (mTOR) and phosphorylated mTOR (Cell Signaling)."
28377392
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"These results suggested that AKT1 and p70S6K involved in the phosphorylation of mTOR jointly and DHA induced inhibition of mTOR might be due to affecting the kinases activity of AKT1 and p70S6K partially."
33658929
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"AKT/protein kinase B (PKB) and ERK1/2, two key upstream kinases of mTOR, can positively regulate mTOR phosphorylation and thus inhibiting autophagic flux."
31921197
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"This leads to the activation of protein kinase B (Akt) which then phosphorylates the mechanistic target of rapamycin (mTor) [XREF_BIBR, XREF_BIBR]."
27980456
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"Akt1 can phosphorylate mTOR, which can then in turn trigger phosphorylation of S6 protein for its activation."
19041640
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"We speculated that RhebL1 might bind to AKT1 directly or indirectly via mTOR since RhebL1 could bind to mTOR and mTOR was phosphorylated by AKT1 [ xref , xref ]."
28209923
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"One of the major functions of Akt1 is to activate the protein synthesis pathways by phosphorylating mTor."
29572181
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"Upon activation through phosphorylation, pAkt promotes cell survival by inactivating the pro‐apoptotic proteins Bad, c‐Raf and caspase‐9 (Burgering & Bos, 1995; Cardone et al., 1998; Franke & Cantley, 1997; Zimmermann & Moelling, 1999) and activates mammalian target of rapamycin (mTOR) phosphorylation (Heinonen et al., 2008)."
36533845
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"Inhibition of protein kinase B (AKT) and SRC in the presence of gemcitabine significantly reduced the metastatic potential of pancreatic cancer cells by suppressing the phosphorylation of mTOR and ERK in cells [67]."
36015174
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"In addition, AKT1 could promote the phosphorylation of mTOR [ 31 ]."
36399797
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"Among various cellular functions, activated AKT-1 can phosphorylate mammalian target of rapamycin (mTOR), which regulates cell proliferation by phosphorylation of p70S6 in the G1/S phase transition of[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22445095
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"AKT1 directly phosphorylates the mammalian target of rapamycin (mTOR), which in turn phosphorylates and activates p70 S6 kinase (p70S6K) that then targets and phosphorylates ribosomal protein S6 at Ser240/Ser244 [ xref , xref ]."
36497091
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"AKT1 phosphorylates and activates mTOR."
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