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AKT1 phosphorylates MTOR. 19 / 19
1 | 13 3 2

sparser
"Interestingly, we found the active form of MTOR, phospho-(Ser2448)-MTOR, at the base of primary cilia in wild-type MEFs ( xref ) making it likely that phospho-(Ser473)-AKT1 phosphorylates MTOR at primary cilia."

reach
"Furthermore, upstream overexpression or knockdown of Akt2 or Akt2 phosphorylation inhibition, rather than Akt1 or Akt3, resulted in striking hyperphosphorylation or dephosphorylation of mTOR, p70S6K and rpS6 (all P < 0.05), without any change in total proteins expressions."

reach
"In Figures XREF_FIG, application of the phosphoinositide 3-kinase (PI 3-K) inhibitor LY294002 (10 muM) during treatment with either EPO (10 ng/ml) or Wnt1 (100 ng/ml) prevented EPO or Wnt1 from phosphorylating mTOR and p70S6K, illustrating that the PI 3-K and Akt1 pathways are necessary for EPO or Wnt1 to phosphorylate mTOR and p70S6K."

reach
"Despite modulation of PRAS40, which regulates the mTOR containing TORC1 complex, mutational activation of PIK3CA or AKT1 did not consistently increase phosphorylation of mTOR at serine 2448 or phosphorylation of mTOR target proteins and their targets, including p70-ribosomal protein S6-kinase (p70S6K), eukaryotic elongation factor 4 binding protein 1 (EIF4EBP1), and ribosomal protein S6."

sparser
"We speculated that RhebL1 might bind to AKT1 directly or indirectly via mTOR since RhebL1 could bind to mTOR and mTOR was phosphorylated by AKT1 [ xref , xref ]."

rlimsp
"In addition, our analysis on Hsp90 associated PI3K/Akt/mTOR signaling pathway demonstrated that CHIKV infection stabilizes Raf1 and activates Hsp90 client protein Akt, which in turn phosphorylates mTOR. Subsequently, this phosphorylation leads to the activation of two important downstream effectors, S6K and 4EBP1, which may facilitate translation of viral as well as cellular mRNAs."

reach
"Furthermore, we found the phosphorylation of mammalian target of rapamycin (mTOR), protein kinase B (AKT) and extracellular signal-regulated kinase (ERK), as well as activation of rat sarcoma virus (RAS) were all reduced dramatically after AT treatment in vitro."

reach
"This leads to the activation of protein kinase B (Akt) which then phosphorylates the mechanistic target of rapamycin (mTor) [XREF_BIBR, XREF_BIBR]."

reach
"One of the major functions of Akt1 is to activate the protein synthesis pathways by phosphorylating mTor."

reach
"These results suggested that AKT1 and p70S6K involved in the phosphorylation of mTOR jointly and DHA induced inhibition of mTOR might be due to affecting the kinases activity of AKT1 and p70S6K partially."

reach
"Primary antibodies included glucose transpoter-4, focal adhesion kinase, PGC-1alpha (Santa Cruz Biotechnology), total protein kinase B (AKT), phosphorylated AKT, total mammalian target of rapamycin (mTOR) and phosphorylated mTOR (Cell Signaling)."

reach
"Phosphorylation of mTOR can subsequently be stimulated by the phosphoinositide-3 kinase (PI3K)-mediated activation of protein kinase B (Akt) XREF_BIBR, XREF_BIBR."

"Once phosphorylated, Akt can act on a broad spectrum of substrates that can influence cell survival and proliferation and protein synthesis (65). Phosphorylation of mTOR by Akt leads to mTOR activation (40, 52) and the subsequent activation of p70S6K"

sparser
"Akt1 can phosphorylate mTOR ( xref ), which can then in turn trigger phosphorylation of S6 protein for its activation."

reach
"We have investigated the effects of insulin, amino acids, and the degree of muscle loading on the phosphorylation of Ser (2448), a site in the mammalian target of rapamycin (mTOR) phosphorylated by protein kinase B (PKB) in vitro."

reach
"AKT/protein kinase B (PKB) and ERK1/2, two key upstream kinases of mTOR, can positively regulate mTOR phosphorylation and thus inhibiting autophagic flux."

rlimsp
"In addition, our analysis on Hsp90 associated PI3K/Akt/mTOR signaling pathway demonstrated that CHIKV infection stabilizes Raf1 and activates Hsp90 client protein Akt, which in turn phosphorylates mTOR."

reach
"Western blot analysis was applied to measure the levels of NLRC5, microtubule-associated protein 1A/1B-light chain 3 type I (LC3I), LC3II, sequestosome 1 (p62), protein kinase B (AKT), phosphorylated Akt (pAKT), mammalian target of rapamycin (mTOR) and phosphorylated mTOR (pmTOR)."

reach
"Akt1 can phosphorylate mTOR, which can then in turn trigger phosphorylation of S6 protein for its activation."