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IndraLab

Statements

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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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AKT1 phosphorylates MTOR. 16 / 16
2 1 | 2 3 8
biopax:panther
No evidence text available
sparser
"Interestingly, we found the active form of MTOR, phospho-(Ser2448)-MTOR, at the base of primary cilia in wild-type MEFs ( xref ) making it likely that phospho-(Ser473)-AKT1 phosphorylates MTOR at primary cilia."
reach
"Furthermore, upstream overexpression or knockdown of Akt2 or Akt2 phosphorylation inhibition, rather than Akt1 or Akt3, resulted in striking hyperphosphorylation or dephosphorylation of mTOR, p70S6K and rpS6 (all P < 0.05), without any change in total proteins expressions."
reach
"This leads to the activation of protein kinase B (Akt) which then phosphorylates the mechanistic target of rapamycin (mTor) [XREF_BIBR, XREF_BIBR]."
signor
"Once phosphorylated, Akt can act on a broad spectrum of substrates that can influence cell survival and proliferation and protein synthesis (65). Phosphorylation of mTOR by Akt leads to mTOR activation (40, 52) and the subsequent activation of p70S6K"
reach
"In Figures XREF_FIG, application of the phosphoinositide 3-kinase (PI 3-K) inhibitor LY294002 (10 muM) during treatment with either EPO (10 ng/ml) or Wnt1 (100 ng/ml) prevented EPO or Wnt1 from phosphorylating mTOR and p70S6K, illustrating that the PI 3-K and Akt1 pathways are necessary for EPO or Wnt1 to phosphorylate mTOR and p70S6K."
sparser
"Akt1 can phosphorylate mTOR ( xref ), which can then in turn trigger phosphorylation of S6 protein for its activation."
reach
"We have investigated the effects of insulin, amino acids, and the degree of muscle loading on the phosphorylation of Ser (2448), a site in the mammalian target of rapamycin (mTOR) phosphorylated by protein kinase B (PKB) in vitro."
reach
"Despite modulation of PRAS40, which regulates the mTOR containing TORC1 complex, mutational activation of PIK3CA or AKT1 did not consistently increase phosphorylation of mTOR at serine 2448 or phosphorylation of mTOR target proteins and their targets, including p70-ribosomal protein S6-kinase (p70S6K), eukaryotic elongation factor 4 binding protein 1 (EIF4EBP1), and ribosomal protein S6."
sparser
"We speculated that RhebL1 might bind to AKT1 directly or indirectly via mTOR since RhebL1 could bind to mTOR and mTOR was phosphorylated by AKT1 [ xref , xref ]."
reach
"Primary antibodies included glucose transpoter-4, focal adhesion kinase, PGC-1alpha (Santa Cruz Biotechnology), total protein kinase B (AKT), phosphorylated AKT, total mammalian target of rapamycin (mTOR) and phosphorylated mTOR (Cell Signaling)."
biopax:panther
No evidence text available
reach
"Phosphorylation of mTOR can subsequently be stimulated by the phosphoinositide-3 kinase (PI3K)-mediated activation of protein kinase B (Akt) XREF_BIBR, XREF_BIBR."
rlimsp
"In addition, our analysis on Hsp90 associated PI3K/Akt/mTOR signaling pathway demonstrated that CHIKV infection stabilizes Raf1 and activates Hsp90 client protein Akt, which in turn phosphorylates mTOR. Subsequently, this phosphorylation leads to the activation of two important downstream effectors, S6K and 4EBP1, which may facilitate translation of viral as well as cellular mRNAs."
reach
"Akt1 can phosphorylate mTOR, which can then in turn trigger phosphorylation of S6 protein for its activation."
rlimsp
"In addition, our analysis on Hsp90 associated PI3K/Akt/mTOR signaling pathway demonstrated that CHIKV infection stabilizes Raf1 and activates Hsp90 client protein Akt, which in turn phosphorylates mTOR."