IndraLab

"98 A similar mechanism was described for CY09 which affects the NLRP3 ATPase activity hindering the assembly of NLRP3 itself.99 On CAPS there are currently ongoing studies with Inzomelid ( NCT04015076 ) , another oral selective NLRP3 inhibitors , and tranilast ( NCT03923140 ) , an anthranilic acid able to bind the NACHT domain ; 99 diacerein , an anthraquinone compound , may downregulate both NLRP3 / caspase-1 / IL-1beta either the IL-6 / pSTAT3 axis ,100 while belnacasan ( VX-765 ) and A1-AT target directly the caspase I component blocking the IL-1beta release.95 ,101 Despite the studies on these inflammasome inhibitors currently being at an early stage , it is conceivable they could have future employment in Still 's disease ."

"In a third study, Rhein, a traditional Chinese medicine (lipophilic anthraquinone) found in medicinal herbs that has antiviral activities, inhibited RSV-induced activation of the NLRP3 inflammasome and production of lung IL-33 in mice [115]."