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Modified USP12-C48A increases the amount of PHLPP1. 1 / 1

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"Importantly, overexpression of Usp12 deubiquitinated both PHLPP and PHLPPL and this elevated the steady-state levels of the enzymes, while overexpression of an enzymatically inactive Usp12 C48A mutant failed to elevate PHLPP and PHLPPL levels suggesting the importance of Usp12 enzymatic activity for phosphatase regulation."

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IndraLab

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Modified USP12-C48A increases the amount of PHLPP1. 1 / 1

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