IndraLab

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ATXN3L deubiquitinates KLF5. 9 / 9
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"ATXN3L deubiquitinates KLF5."
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"Ataxin-3 like (<span class="match term0">ATXN3L</span>), a member of the Josephin family of deubiquitinating enzymes, promotes breast cancer proliferation by deubiquitinating Kruppel-like factor 5 (<span class="match term1">KLF5</span>). The Kruppel-like factor 5 (<span class="match term1">KLF5</span>) has been suggested to promote breast cell proliferation, survival and tumorigenesis."
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"For example, ATXN3L and USP3 mediate the deubiquitination of KLF5 and thus regulate the proliferation of BC cells [39,40]."
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"As shown in Figure XREF_FIG, ATXN3L silencing increased the endogenous KLF5 protein ubiquitination."
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"The ATXN3L protein interacted with the KLF5 protein and decreased the KLF5 polyubiquitination."
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"Although ATXN3L decreases the KLF5 protein ubiquitination, ATXN3L may have other substrate proteins."
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"We then sought to determine whether ATXN3L directly decreases the KLF5 ubiquitination."
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"GST-ATXN3L, but not GST-ATXN3L (M4), dramatically decreased the KLF5 protein polyubiquitination."
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"Whether the deubiquitination of KLF5 protein by ATXN3L is regulated is unknown at present."
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