IndraLab

"ATXN3L deubiquitinates KLF5."

"Whether the deubiquitination of KLF5 protein by ATXN3L is regulated is unknown at present."

"We then sought to determine whether ATXN3L directly decreases the KLF5 ubiquitination."

"The ATXN3L protein interacted with the KLF5 protein and decreased the KLF5 polyubiquitination."

"Ataxin-3 like (ATXN3L), a member of the Josephin family of deubiquitinating enzymes, promotes breast cancer proliferation by deubiquitinating Kruppel-like factor 5 (KLF5). Ge F(1)(2), Chen W(3), Qin J(1), Zhou Z(1), Liu R(1), Liu L(4), Tan J(3), Zou T(3), Li H(2), Ren G(2), Chen C(1). Author information: (1)Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China. (2)Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. (3)Department of Breast Surgery, The 3rd Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China. (4)Laboratory for Conservation and Utilization of Bioresource, Yunnan University, Kunming, China. The Kr眉ppel-like factor 5 (KLF5) has been suggested to promote breast cell proliferation, survival and tumorigenesis."

"GST-ATXN3L, but not GST-ATXN3L (M4), dramatically decreased the KLF5 protein polyubiquitination."

"Although ATXN3L decreases the KLF5 protein ubiquitination, ATXN3L may have other substrate proteins."

"As shown in Figure XREF_FIG, ATXN3L silencing increased the endogenous KLF5 protein ubiquitination."