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Statements

Gal-SLPs inhibits USP22. 4 / 4
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"Besides , Gal-SLPs downregulated in vivo USP22 expression to a much greater extent than Gal-LPs ( Figure 7g ) , which was well correlated with the in vitro Western blot analysis , convincingly proving the self-activated cascade-responsive process and synergy of sorafenib and shUSP22 ."
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"Thus , we speculated that the downregulation of USP22 by Gal-SLPs could block the glycolysis and further suppress stemness features in HCC cells ."
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"Thus , Gal-SLPs dramatically suppressed the expression of USP22 ."
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"] Our study provided strong evidence that the downregulation of USP22 by Gal-SLPs suppressed the expression of MRP1 and caused high intracellular sorafenib accumulation ."
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