IndraLab

Statements

CACNA1C activates INS. 3 / 3
| 3
reach
"Further studies confirmed that Cacna1c mRNA and protein are downregulated by miR-153 mimics and upregulated by miR-153 inhibitors in insulin secreting freshly isolated mouse islets, in the insulin secreting mouse cell line MIN6 and in the dopamine secreting cell line PC12."
26141787
reach
"In addition, TCF7L2 upregulates the L-type Ca channel CAV1.2, which promotes insulin efflux through exocytosis (81–83)."
34568447
reach
"miR-26a is expressed in β-cells and inhibits expression of voltage-gated L-type calcium channel subunit-α1C (CACNA1C), which mediates calcium influx and insulin granule fusion ."
33772227