IndraLab

Statements

CACNA1C activates INS. 3 / 3
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reach
"In addition, TCF7L2 upregulates the L-type Ca channel CAV1.2, which promotes insulin efflux through exocytosis (81–83)."
34568447
reach
"Further studies confirmed that Cacna1c mRNA and protein are downregulated by miR-153 mimics and upregulated by miR-153 inhibitors in insulin secreting freshly isolated mouse islets, in the insulin secreting mouse cell line MIN6 and in the dopamine secreting cell line PC12."
26141787
reach
"miR-26a is expressed in β-cells and inhibits expression of voltage-gated L-type calcium channel subunit-α1C (CACNA1C), which mediates calcium influx and insulin granule fusion ."
33772227