IndraLab

Statements

BAP1 binds TNPO1. 7 / 7
5 | 2
biogrid
No evidence text available
35446349
biogrid
No evidence text available
35446349
biogrid
No evidence text available
35446349
biogrid
No evidence text available
35446349
biogrid
No evidence text available
34591877
sparser
"Having established the multi-mUb of BAP1 699–729 by UBE2O, we asked whether TNPO1 binding to BAP1 699–729 would down-regulate the ubiquitin ligase activity of UBE2O. Preincubation of the FITC-labeled BAP1 699–729 with one or two molar ratios of TNPO1 for 1 h before initiating the mUb by UBE2O resulted in a substantially reduced level of multi-mUb of BAP1 699–729 in a TNPO1 dose–dependent manner ( xref ; and xref )."
35446349
sparser
"Our structural and biochemical findings collectively demonstrated that TNPO1 binding to the NLS of BAP1 renders the mUb by UBE2O, which has direct implications in promoting BAP1 nuclear localization."
35446349