IndraLab

Statements

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"For example, USP13 inhibited lung inflammation via stabilization of the anti-inflammatory receptor IL-1R8/single immunoglobin interleukin-1-related receptor (Sigirr) (116)."
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"We have shown that USP13 deficiency promotes lung inflammation."
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"USP13 reduces septic mediated cardiomyocyte oxidative stress and inflammation by inducing Nrf2."
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"Li et al. demonstrated that the deubiquitinase USP13 inhibits lung inflammation via stabilizing the anti-inflammatory receptor Sigirr [30]."
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"Upregulation of USP13 repressed inflammatory response in H-FLSs upon TNF-α or IL-1β challenge due to the improvement of PTEN and reduction of AKT phosphorylation as well as inactivation of NF-κB pathway (102)."
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"Furthermore, the deubiquitinating enzyme USP13 stabilizes the anti-inflammatory receptor IL-1R8/Sigirr to suppress lung inflammation [40,41,42]."
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"The deubiquitinase USP13 stabilizes the anti-inflammatory receptor IL-1R8 and Sigirr to suppress lung inflammation."
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"For example, the deubiquitinating enzyme Ubiquitin Specific Peptidase 13 (USP13) stabilizes the anti-inflammatory receptor immunoglobin interleukin-1-related receptor (IL-1R8/Sigirr) to inhibit lung inflammation (162)."
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"USP13 overexpression evidently inhibited lipid accumulation and inflammation in FFA-treated L02 cells in vitro."
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"Further studies showed that USP13 reduced LPS-induced oxidative stress and inflammation by inducing Nrf2."
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"In a series of mice models with NASH phenotype, hepatocyte-specific deficiency of USP13 dramatically potentiated hepatosteatosis, hepatic inflammation, and hepatofibrosis, whereas USP13 overexpression in hepatocytes efficiently suppressed NASH diet-induced steatohepatitis."
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"To summarize, USP13 suppressed liver steatosis, inflammation, and insulin resistance to demonstrate efficacy in treating ob/ob mice."
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"We then showed that over-expressing USP13 markedly suppressed inflammatory response, oxidative stress and apoptosis in H-FLSs upon IL-1beta or TNF-alpha challenge, whereas USP13 knockdown exhibited detrimental effects."
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"Moreover, inhibiting the phosphorylation of TAK1 reversed the aggravation of hepatic steatosis and inflammation induced by USP13 deficiency."
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"Additionally, inflammation was similarly attenuated by USP13 overexpression and aggravated by its deficiency in HFD-fed mice."
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