IndraLab

Statements


USP25 inhibits TRAF5. 3 / 4
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"Meanwhile, USP25 also inhibits TRAF5 activity and affects post-transcriptional RNA stability."

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"In addition to TRAF6 dependent transcriptional regulation, IL-17-triggered signaling promotes stabilization of chemokine mRNA via TRAF5, which was also restricted by USP25."

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"Zhong et al35 reported that USP25 negatively regulates the IL-17-mediated signaling by regulating the K63 modification of TRAF5 and TRAF6 in experimental autoimmune encephalomyelitis."