IndraLab

Statements

PHGDH binds EIF3F. 4 / 4
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"Thus, therapeutic approaches targeting eIF3f‐PHGDH axis represent an attractive strategy for eIF3f‐overexpressing CRC patients and further developing compounds that suppress eIF3f‐mediated PHGDH stabilization and inhibit Wnt signals are worthy of more investigation."
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"Further, co‐IP result confirmed the interaction between eIF3f and FBXW7β suggesting that eIF3f, FBXW7 and PHGDH may form a complex (Figure S3H, Supporting Information)."
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"Our data shed light on eIF3f upstream regulatory circuit and reveal how EGF/Wnt oncogenic signal in promoting eIF3f‐PHGDH axis to enhance the SGOC pathway, thereby affecting tumorigenesis ( Figure xref )."
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"In summary, the present study demonstrates that eIF3f is a critical oncogenic factor and provides strong evidence for eIF3f‐PHGDH axis as a novel therapeutic target for CRC patients."
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