IndraLab

Statements

STX1A binds CACNA1B. 5 / 5
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sparser
"In the DII-DIII linker, PKC phosphorylates the sites identified in mouse brain as S773 and S892, and CaMKII at S783, and impacts syntaxin1A–Cav2.2 interaction ( xref )."
21149544
sparser
"Past efforts to harness uncoupling of the syntaxin 1A-Cav2.2 interaction for therapeutic use have not advanced despite an early report of success [ xref ]."
30364788
sparser
"Neurofibromin sequesters CRMP2 from syntaxin 1A. On loss of neurofibromin, as observed in patients with NF1, the CRMP2/neurofibromin interaction is uncoupled, which liberates CRMP2 to interact with both syntaxin 1A and Cav2.2, culminating in increased release of the pronociceptive neurotransmitter CGRP."
28767512
sparser
"Interactions between Cav2.2 and the synaptic protein syntaxin 1A then follow to produce fast, synchronous neurotransmitter release [ xref – xref ]."
30364788
sparser
"Neurofibromin uncouples CRMP2 from syntaxin 1A. Upon loss/mutation of neurofibromin, as seen in patients with NF1, the CRMP2/Neurofibromin interaction is uncoupled, which frees CRMP2 to interact with both syntaxin 1A and CaV2.2, culminating in increased release of the pro-nociceptive neurotransmitter calcitonin gene related peptide (CGRP)."
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