IndraLab
Statements
sparser
"Hence, if p53 TAD anchors additional binding sites for σ and τ that are created upon DNA damage, it is possible that binding of σ and τ to p53 TAD could competitively inhibit the binding of MDM2 to p53 TAD, resulting in increased p53 levels, similar to competitive binding of p300 and MDM2 to p53 TAD ( xref )."
sparser
"More recently, the association of p53 and MDM2 in chromatin was found to correlate with repression of transcription, whereas the absence of association of p53 and MDM2 in chromatin correlated with activation of transcription ( xref ), suggesting that functional association of MDM2 or p300 with p53 is mutually exclusive."