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OTUB1 inhibits SLC7A11. 15 / 15
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"84 Liang et al. 85 found that SM inhibited the transcriptional regulation of Transcription factor activating enhancer binding protein 2 alpha (TFAP2A) to OTU domain, ubiquitin aldehyde binding 1 (OTUB1) in human pancreatic cancer cells (PANC‐1 and CFPAC‐1), which in turn inhibited the deubiquitination of SLC7A11 proteins by OTUB1, induced SLC7A11 degradation, activating iron death and inhibiting pancreatic cancer cell progression.3.5 Colorectal cancer."
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"As shown in XREF_FIG, the steady-state levels of SLC7A11 in OTUB1 depleted cells were significantly restored upon treatment with the MG132 proteasome inhibitor (lane 4 vs. lane 2), indicating that OTUB1 depletion promotes SLC7A11 degradation in a proteasome dependent manner."
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"Solasonine, an alkaloid constituent of Solanum nigrum L., has induced ferroptosis in PC cell lines through degradation of SLC7A11 by Otubain-1 (OTUB1)-mediated ubiquitination ( Liang et al., 2022 )."
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"Furthermore, Co-Immunoprecipitation and Duolink (R) in situ PLA confirmed that OTUB1, a deubiquitylating enzyme, interacted with SLC7A11 and solasonine to enhance ubiquitinated degradation of SLC7A11 in PANC-1 and CFPAC-1 cells."
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"The deubiquitinating enzyme OTUB1 interacts with SLC7A11 to cause SLC7A11 degradation [ 300 ]."
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"The interplay between ubiquitination and deubiquitination regulates intracellular protein catabolism and modulates ferroptosis.Studies have shown that the deubiquitinating enzyme OTUB1 inhibits ferroptosis by stabilizing SLC7A11 [67]."
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"OTUB1 was previously shown to interfere with ubiquitination and subsequent proteasomal degradation of SLC7A11 (22)."
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"Like CD44, OTUB1 is also overexpressed in human cancers and acts to suppress ferroptosis by promoting SLC7A11 stability."
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"In this case, solasonine enhanced the degradation of OTUB1-mediated SLC7A11 via TFAP2A, activating ferroptosis in pancreatic cancer (Liang et al., 2022)."
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"The tumour stem cell molecules CD44 [91,92,93] and OTU deubiquitinase ubiquitin aldehyde binding 1 (OTUB1) [94] were beneficial to the stability of SLC7A11 on the cell membrane, and inhibited the proteasomal degradation of SLC7A11."
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"96 Other SLC7A11/system Xc regulators include CD44 and OTUB1, which suppress ferroptosis by directly binding the SLC7A11 protein and increasing the stability of the latter.97 98 Beclin-1 (BECN1), a key autophagy regulator, on the other hand, inhibits system Xc by binding SLC7A11, and consequently promotes ferroptosis induced by system Xc inhibitors.99 GPX4 regulators."
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"Solasonine, a steroidal alkaloid, inhibits the expression of transcription factor AP-2 alpha (TFAP2A) and the subsequent transcription of the deubiquitinating enzyme OTUB1, which induces SLC7A11 degra[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Zhao et al. (32) indicated that OTUB1 inhibits ferroptosis and promotes stemness of glioma cells by stabilising the SLC7A11 protein."
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"Moreover, depletion of endogenous OTUB1 diminishes SLC7A11 activity in human cancer cells."
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"Zhao et al. found that the ubiquitin hydrolase OTUB1 inhibits ferroptosis by stabilizing the SLC7A11 protein and promoting glioma cell stemness (67).2.4.4 Circular RNA."
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