IndraLab

Statements

OTUB1 inhibits SLC7A11. 4 / 4
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"Like CD44, OTUB1 is also overexpressed in human cancers and acts to suppress ferroptosis by promoting SLC7A11 stability."
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"As shown in XREF_FIG, the steady-state levels of SLC7A11 in OTUB1 depleted cells were significantly restored upon treatment with the MG132 proteasome inhibitor (lane 4 vs. lane 2), indicating that OTUB1 depletion promotes SLC7A11 degradation in a proteasome dependent manner."
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"Furthermore, Co-Immunoprecipitation and Duolink ® in situ PLA confirmed that OTUB1, a deubiquitylating enzyme, interacted with SLC7A11 and solasonine to enhance ubiquitinated degradation of SLC7A11 in PANC-1 and CFPAC-1 cells."
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"Moreover, depletion of endogenous OTUB1 diminishes SLC7A11 activity in human cancer cells."
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