IndraLab

Statements

OTUD5 activates DNA repair. 5 / 5
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"In addition to its role in promoting the signaling axis of the DDR, we found that OTUD5 promotes the efficiency of DNA repair exclusively at telomeres and heterochromatin, but not in general, non-specific chromatin contexts."
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"Taken together, we conclude that OTUD5 is required both for efficient NHEJ and for efficient MMEJ at deprotected telomeres.Having established that OTUD5 promotes DNA repair by NHEJ and MMEJ at telomeres, we assessed if the role of OTUD5 in DNA repair extends beyond a telomeric context, especially since we found OTUD5 to promote both telomere-specific and genome-wide DDR activation in mouse and human cells."
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"Moreover, we found that OTUD5 promotes DNA repair at deprotected telomeres and at heterochromatin."
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"If OTUD5 indeed promotes ATM-dependent DDR and telomeric DNA repair through the UBR5-ATMIN axis, ablation of ATMIN is expected to reverse the DDR defects exhibited by OTUD5-depleted cells."
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"Hence, we next considered the possibility that KAP1, the central factor of our screening approach, is itself of key importance for how OTUD5 promotes efficient DNA repair activity at telomeres."
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