IndraLab

Statements

KCND2 binds AKAP79/150. 4 / 4
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sparser
"Because AKAP79/150 interacts with Kv4.2 and plays a dominant role in localizing PKA in dendrites and dendritic spines ( xref ; xref ; xref ), these Ht31 results indicate that AKAP79/150 is likely to be the primary AKAP responsible for Kv4.2 regulation in hippocampal neurons."
21273417
sparser
"If and how Kv4.2 trafficking by AKAP79/150 affects synaptic plasticity will require additional tools designed to specifically impact AKAP79/150-Kv4.2 interaction to distinguish results from AKAP effects on AMPAR expression."
21273417
sparser
"Kv4.2-AKAP79/150 interaction requires a region overlapping with the MAGUK binding domain of AKAP79/150."
21273417
sparser
"PKA anchoring by AKAP79/150 or phosphorylation of Kv4.2 at site PKA S552 are not, however, necessary for AKAP79/150-Kv4.2 interaction."
21273417