IndraLab

Statements

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"For instance, USP19 inhibits the degradation of TGF-beta activated kinase 1, thereby modulating the NF-kB signaling pathway and immune responses (4)."
39389361
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"USP19 negatively regulates the activation of TAK1-TAB1 dependent NF-κB signaling pathway by specifically removing TAK1 coupled Lys63 and Lys27 linked polyubiquitin chains, resulting in impaired TAK1 activity and destruction of the TAK1-TAB2/3 complex (207)."
39185411
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"USP19/ZMYND9 also negatively regulates signaling pathway of type I interferon (IFN) with dependence of Beclin-1 [149]."
36520265
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"Furthermore, USP19 deficiency in macrophages caused an elevation of TBK1 and the activation of the type-I interferon signaling pathway after vesicular stomatitis virus (VSV) infection."
34436957