IndraLab

Statements

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"However, studies have demonstrated that USP8 promotes the transformation of microglia from the M1 phenotype to the M2 phenotype through the TLR4/MyD88/NF-KB pathway, thereby alleviating inflammation and movement disorders induced by LPS [137]."
36260224
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"USP8 alters the splenic structure in the LPS-induced systemic inflammation model."
36321796
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"In liver fibrosis models and activated Kupffer cells (KCs), the elevated expression of METTL3 enhances metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) levels via m6A methylation and facilitates the degradation of ubiquitin-specific peptidase 8 (USP8) mRNA, subsequently reduces transforming growth factor β-activated kinase 1 (TAK1) regulation, enhances cell pyroptosis markers (NLRP3, caspase-1, GSDMD-N) and NF-κB p-p65 levels, thereby promoting macrophage pyroptosis and inflammation [58]."
40001550
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"OTUD4 and Cezanne remove K63-linked polyubiquitin chains on tumour necrosis factor receptor-associated factor 6 (TRAF6), alleviating inflammation and IRI in the liver and kidney respectively [144,145], and USP8 alleviates intermittent hypoxia/reoxygenation induced inflammation by removing K63-linked ubiquitination of TAK1 [146]."
39584532
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"A previous report showed that USP8 protected against LPS-induced inflammatory response in vitro and in vivo via the reductions of TNF-α, IL-1β, PGE2, and NO [73]."
34688043
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"The present study is the first, to the best of our knowledge, to investigate the effects of ubiquitin specific peptidase 8 (USP8) on IHR induced inflammation in renal tubular epithelial cells and examine the underlying mechanism."
30221684
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"Effect of deubiquitinase USP8 on hypoxia and reoxygenation induced inflammation by deubiquitination of TAK1 in renal tubular epithelial cells."
30221684