IndraLab

Statements

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"Additionally, DHA in vivo improved the clinical symptoms, reduced the production of pro inflammatory factors IL-1beta, IL-6 and TNF-alpha, and suppressed the formation of NLRP3 inflammasome."
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"Interestingly, the ability of EPA and DHA to inhibit NLRP3 inflammasome activation was not dependent upon their enzymatic metabolism to lipid mediators (e.g., resolvins), but was, in part, dependent upon a GPR120 mediated interaction between betaarr2 and NLRP3 [XREF_BIBR]."
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"However, DHA could inhibit the NLRP3 inflammasome independently of these metabolites."
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"More recently, Quingyao et al. assumed that DHA-mediated NLRP3 inflammasome inhibition was due to the blockade of high glucoseinduced TXNIP via the PI3K/Akt pathway in pre-adipocytes [103] ."
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"For example, a recent study has shown that EPA and DHA inhibit the NLRP3 inflammasome in macrophages, independently from their enzymatic products."
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"Since long-chain FAs can activate GPR120 and GPR40 [96] and GPR120 is also involved in the anti-inflammatory effects of ω-3 FAs [93] , they tested the role of both receptors on DHA-induced NLRP3 in[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Since long-chain FAs can activate GPR120 and GPR40 [96] and GPR120 is also involved in the anti-inflammatory effects of omega-3 FAs [93], they tested the role of both receptors on DHA induced NLRP3 in[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"XREF_BIBR, XREF_BIBR Remarkably, both the NLRP3 inflammasome and mTORC1 are activated by palmitic acid and inhibited by DHA, respectively."
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"To date, only one study has shown that gavage of DHA in high-fat diet fed mice attenuated NLRP3 inflammasome activation and prevented mice from high-fat diet induced insulin resistance at a whole-body level."
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"Recently DHA was reported to inhibit NALP3 inflammasome activation in LPS primed bone-marrow-derived macrophages [49]."
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"showed that DHA suppressed NLRP3 inflammasome by inhibiting NF-kappab activation and enhancing autophagy in macrophages."
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