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Amide activates USP14. 1 / 1

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"Conversely, methylene-spaced amide substitution at the 2-position of the pyrimidine ring (50) was found to increase USP14 potency.As part of MISSION Therapeutics’ research into developing drug-like inhibitors of several DUBs, we have successfully co-crystallised an example from this fused thiophene pyrimidine series into USP14 CD and have a 3."

26852935

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IndraLab

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Amide activates USP14. 1 / 1

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