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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Amide activates USP14. 1 / 1

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"Conversely, methylene-spaced amide substitution at the 2-position of the pyrimidine ring (50) was found to increase USP14 potency.As part of MISSION Therapeutics’ research into developing drug-like inhibitors of several DUBs, we have successfully co-crystallised an example from this fused thiophene pyrimidine series into USP14 CD and have a 3."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...