IndraLab

Statements

NFkappaB binds SCN5A. 4 / 4
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sparser
"Elevated angiotensin II levels and the increased oxidative stress increase NF-κB binding to the SCN5A promoter region, thereby decreasing its transcriptional activity (Shang et al., xref )."
27536244
reach
"Angiotensin II (AngII) or H 2 O 2 treatment of cardiomyocytes results in increased NF-kappaB binding to SCN5A promoter with subsequent reduction in transcriptional activity [XREF_BIBR]."
21978629
sparser
"This is in agreement with another study xref that demonstrated that NFκB can directly bind to the SCN5A promoter, which is involved in down-transcription of the Na v 1.5 channel in rat ventricular cells."
24101667
sparser
"Angiotensin II (AngII) or H 2 O 2 treatment of cardiomyocytes results in increased NF-κB binding to SCN5A promoter with subsequent reduction in transcriptional activity [ xref ]."
21978629