IndraLab

Statements

SCN5A binds NFkappaB. 8 / 8
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sparser
"Oxidative stress also affects I Na by modulating the expression of the major in the heart, Na V 1.5 encoded by SCN5A . Ang II and H 2 O 2 promote the binding of NF-kB to the cardiac Scn5a promoter, reducing Scn5a mRNA levels [ xref ]."
37891912
sparser
"H 2 O 2 and angiotensin II (AngII) downregulate a cardiac Na + channel (SCN5A) transcription in isolated ventricular myocytes through NF-κB binding to SCN5A promoter, resulting in arrhythmia by reducing the total sodium current and slowing the CV xref ."
38694269
sparser
"Treatment of cardiomyocytes with angiotensin II (Ang II) or hydrogen peroxide led to increased binding of NF-κB to the SCN5A promoter and subsequently decreased transcriptional activity."
40109091
sparser
"Elevated angiotensin II levels and the increased oxidative stress increase NF-κB binding to the SCN5A promoter region, thereby decreasing its transcriptional activity (Shang et al., xref )."
27536244
reach
"Angiotensin II (AngII) or H 2 O 2 treatment of cardiomyocytes results in increased NF-kappaB binding to SCN5A promoter with subsequent reduction in transcriptional activity [XREF_BIBR]."
21978629
sparser
"This is in agreement with another study xref that demonstrated that NFκB can directly bind to the SCN5A promoter, which is involved in down-transcription of the Na v 1.5 channel in rat ventricular cells."
24101667
sparser
"NF-κB bound to the SCN5A promoter region [179] and reduced Nav1.5 expression and I Na density in H9c2 myocytes [180] ."
35963339
sparser
"Angiotensin II (AngII) or H 2 O 2 treatment of cardiomyocytes results in increased NF-κB binding to SCN5A promoter with subsequent reduction in transcriptional activity [ xref ]."
21978629