IndraLab

Statements

CDK4 phosphorylates RB1 on S249. 4 / 4
1 1 | 1 1
reach
"Indeed, RB phosphorylated at specific sites by CDK4 and CDK6 (serine 249 and threonine 252) was inversely correlated with PD-L1 expression in samples from prostate cancer patients [65] ."
38135020
sparser
"CDK4–cyclin D1 phosphorylates Thr 5 , Ser 249 , Thr 252 , Thr 356 , Thr 373 , Ser 788 , Ser 795 , Ser 807 , Ser 811 , and Thr 826 of pRB."
18938028
signor
"Phosphorylated by cdk6 and cdk4, and subsequently by cdk2 at ser-567 in g1, thereby releasing e2f1 which is then able to activate cell growth. Here we show that although these cdks phosphorylate multiple residues in prb, they do so with different residue selectivities in vitro;thr821 and thr826 are preferentially phosphorylated by cdk6 and cdk4, respectively."
15809340
biopax:phosphositeplus
No evidence text available