IndraLab

Statements

reach
"In contrast, genetic or chemical inhibition of USP5 leads to CCND1 degradation, thereby resulting in decreased NSCLC cell proliferation and tumor growth."
34858787
reach
"Targeting USP5 suppresses AKT/mTOR/4EBP1 signaling and reduces the proliferation and growth of AML cells."
38926952
reach
"Our experiments further confirmed that USP5 knockdown could suppress ovarian cell proliferation both in vitro and in vivo."
31727867
sparser
"The siRNA-induced knockdown of Usp5 inhibited cell proliferation, migration ability and drug resistance."
28881591
reach
"This study showed genetic ablation of USP5 significantly inhibited the viability and proliferation of bladder cancer cells."
40136465
reach
"Down-regulation of USP5 inhibited cell proliferation of ovarian cancer cells."
31727867
reach
"As shown in Figure 3B, NC had little effect on USP5 expression compared to the Control group, and USP5 shRNAs (#1, #2 and #4) reduced USP5 protein expression in both cell lines.Following USP5 shRNAs (#1 and #2) transduction, the proliferation of both cancer cell lines was determined using CCK-8 assays, which showed that down-regulation of USP5 caused profoundly reduced proliferation of both ovarian cancer cell lines (Figure 3C, P<0.001)."
31727867
reach
"Genetic ablation of USP5 markedly inhibited bladder cancer cell proliferation, viability, and migration both in vitro and in vivo."
38229092
reach
"Regarding the proliferative capacity of the cells, the CCK-8 experiments demonstrated that USP5 overexpressing T24 cells had significantly increased proliferation and USP5 knockdown T24 cells had significantly decreased proliferation compared with the control group (P<0.05; Fig. 2D)."
39397799
reach
"A series of phenotypic experiments showed that USP5 overexpression attenuated the inhibition of proliferation and invasion of Huh‐7 and HCC‐LM3 cells in the absence of METTL5 (Supplementary Figure S17)."
36602428
reach
"PTB knockdown causes a decrease in USP5 isoform 2 and an increase in USP5 isoform 1, which further inhibits cell proliferation [ 60 ]."
31756387
reach
"These chalcone derivatives effectively inhibit the activity of DUB, such as USP5, UCH-L3, USP2, UCH-L1, and USP8, leading to irreversible cell cycle arrest in breast, ovarian, and cervical cancer cells (IC50 = 1.5-12.5 µM), as well as inhibiting their proliferation and initiating apoptosis."
39391229