IndraLab

Statements

USP14 activates autophagy. 9 / 9
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"Akt regulated USP14 activity can modulate both proteasomal degradation and autophagy through controlling K48 and K63 ubiquitination, respectively."
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"These findings provided a unique mechanism underlying the connections among USP14-mediated autophagy, DDR-related ubiquitin signaling, and DNA repair (Figure 5)."
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"However, inhibition of USP14 rescues the DDR defects in autophagy-deficient PC cells (Sharma et al., 2018)."
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"The deubiquitinating enzyme ubiquitin specific peptidase 14 (USP14) has been shown to modulate both proteasome activity and autophagy."
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"USP14-Mediated Autophagy in Lung Cancer."
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"Knockdown of USP14 or its inhibition with the inhibitor IU1 (see below Section 4.1) induces the activation of autophagy, indicating that USP14 is a negative regulator of autophagy in H4 (neuroglioma) cells."
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"USP14-Mediated Autophagy in DNA Repair."
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"The authors ascribed these phenotypes to TRIM14 's role in promoting cGAS stabilization and provide evidence that loss of TRIM14 allows for cGAS degradation via the E3 ligase USP14, which targets cGAS to p62 dependent selective autophagy."
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"USP14-Mediated Autophagy in Inflammation."
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