IndraLab

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USP14 activates autophagy. 18 / 18
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"Akt regulated USP14 activity can modulate both proteasomal degradation and autophagy through controlling K48 and K63 ubiquitination, respectively."
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"To address whether downregulation of proteasome-associated DUBs ubh-4, the uchl5 homolog, and usp-14 induces a tissue-specific or systemic effect on autophagy in C. elegans, we downregulated ubh-4 and usp-14 by RNAi-feeding and analyzed autophagy in intestinal cells, hypodermal seam cells and pharynx (Fig. 4A)."
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"To investigate whether Uchl5 or Usp14 knockdown causes a block in autophagy or potentially affect the number of lysosomes, we first performed immunofluorescence analysis against lysosome-associated membrane protein 2 (LAMP2)."
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"USP14-Mediated Autophagy in DNA Repair."
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"The deubiquitinating enzyme ubiquitin specific peptidase 14 (USP14) has been shown to modulate both proteasome activity and autophagy."
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"However, inhibition of USP14 rescues the DDR defects in autophagy-deficient PC cells (Sharma et al., 2018)."
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"Besides, downregulation of USP14 also induced autophagy via ubiquitinated proteins/ER stress/unfolded protein response (UPR) axis by activation of c-Jun N-terminal kinase 1 (JNK1) [34, 35]."
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"These findings provided a unique mechanism underlying the connections among USP14-mediated autophagy, DDR-related ubiquitin signaling, and DNA repair (Figure 5)."
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"USP14-Mediated Autophagy in Lung Cancer."
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"RAS-ERK-mTOR cross-talk may play a crucial role in TGT-induced hepatocyte autophagy, offering a promising target for developing novel therapeutics to combat TGT-induced hepatotoxicity."
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"USP14-Mediated Autophagy in Inflammation."
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"6-Gingerol inhibits the growth of NSCLC and solid tumors by inhibiting the expression of USP14 and promoting autophagy-dependent ferroptosis [107]."
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"Our data reveal that Uchl5 and Usp14 siRNA treatments or pharmacological inhibition reduce autophagy by blocking autophagosome–lysosome fusion in GFP-LC3-RFP-LC3ΔG HeLa cells."
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"In contrast, downregulation of Usp14 has also been shown to enhance autophagy in human H4 neuroglioma cells, as increased LC3-II levels concomitant with reduced p62 levels were detected (Xu et al., 2016)."
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"It is unlikely that the impact of Usp14 on autophagy would override that of Uchl5, as our siRNA results show that both Usp14 and Uchl5 knockdown reduces autophagy."
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"Knockdown of USP14 or its inhibition with the inhibitor IU1 (see below Section 4.1) induces the activation of autophagy, indicating that USP14 is a negative regulator of autophagy in H4 (neuroglioma) cells."
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"The authors ascribed these phenotypes to TRIM14 's role in promoting cGAS stabilization and provide evidence that loss of TRIM14 allows for cGAS degradation via the E3 ligase USP14, which targets cGAS to p62 dependent selective autophagy."
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"I/R suppressed the expressions of USP14, FTH1, and increased the expressions of Beclin1, LC3II/I and TfR1, which were significantly reversed by EPI treatment, suggesting that EPI inhibited autophagy and ferroptosis in MI/RI rat model (Figure 3A, 3B)."
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