IndraLab

Statements

USP4 activates IFNB1. 2 / 2
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"Thus, USP4 positively regulates IFN-beta signaling by interacting with the N-terminal domain of RIG-I, subsequently leading to the inhibition of RIG-I degradation."
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"Similarly , in vesicular stomatitis virus ( VSV ) infection , removing K48-linked polyubiquitin chains from RIG-I allows USP4 to enhance RIG-I-triggered IFN-beta signaling , thereby inducing an antiviral immune response ( Wang et al ., 2013 ) ."
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