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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP4 activates IFNB1. 2 / 2

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"Thus, USP4 positively regulates IFN-beta signaling by interacting with the N-terminal domain of RIG-I, subsequently leading to the inhibition of RIG-I degradation."

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"Similarly , in vesicular stomatitis virus ( VSV ) infection , removing K48-linked polyubiquitin chains from RIG-I allows USP4 to enhance RIG-I-triggered IFN-beta signaling , thereby inducing an antiviral immune response ( Wang et al ., 2013 ) ."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...