IndraLab

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CACNA1G activates calcium(2+). 9 / 9
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"It is therefore tempting to speculate that enhanced expression of calcium channel subunits, especially Cacna1g which mediates a low-threshold calcium current, as well as other channels that flux calcium are required early in development when synaptic input is minimal, but that the need for these subunits is supplanted once synaptic inputs and firing patterns mature."
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"Similarly, the calcium channel γ 6 subunit inhibits Cav3.1 low voltage-activated calcium current in human embryonic kidney cells and cardiomyocytes using a critical GxxxA motif in TM1."
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"However, nicotine showed bidirectional effects on the expression of genes involved in VDCC mediated calcium signaling and the Ca +2 / calmodulin dependent kinase signaling pathway, with 46%-57% upregulation of Camk4 and Cacnali expression in the hippocampus, 20%-25% upregulation of Calm1 and Camk2g expression in the amygdala, and 56%-73% downregulation of Camk2b, Camk4, Calm2, and Cacna1g expression in the PFC."
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"The depolarization also activates voltage-gated calcium channels, primarily Cav2.1 and Cav3.1, allowing calcium into Purkinje neurons."
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"Live GCaMP imaging of regenerating fins showed T-type Cacna1g channels enable Ca 2+ dynamics in distal fibroblast-lineage blastemal mesenchyme during the outgrowth phase."
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"CACNA1G is a low voltage-gated Ca channel, also known as Cav3.1, that mediates the entry of Ca into excitable cells [21]."
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"Specifically, adult ablation of P/Q channels does not promote Cacna1g mediated burst firing or T-type calcium current (IT) in the thalamocortical relay neurons; however, burst firing in thalamocortical relay neurons remains essential as iKOp/q mice generated on a Cacna1g deleted background show substantially diminished seizure generation."
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"Inactivation kinetics of barium currents induced by Ca V 2.3 expression is faster than for Ca V 1.2 or Ca V 3.1 but slower than for Ca V 3.2 and Ca V 3.3 ( Lee et al., 1999a ; Berrou et al., 2001 )."
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"However, nicotine showed bidirectional effects on the expression of genes involved in VDCC mediated calcium signaling and the Ca +2 / calmodulin dependent kinase signaling pathway, with 46%-57% upregulation of Camk4 and Cacnali expression in the hippocampus, 20%-25% upregulation of Calm1 and Camk2g expression in the amygdala, and 56%-73% downregulation of Camk2b, Camk4, Calm2, and Cacna1g expression in the PFC."
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