IndraLab

"Had the activity of MAFbx been increased, eIF3f should have been increasingly ubiquitinated and degraded at the proteasome [ xref ]."

"Hence any reports describing pathological phenotypes stemming from altered expression of these three subunits should be at least partially regarded as a failure of the dramatically compromised eIF3 complex to ensure productive general translation initiation in sick cells; like underexpression of eIF3f in gastric, melanoma and pancreatic cancers supposedly deregulating apoptosis ( xref , xref ), eIF3f ubiquitination and proteosomal degradation during muscle atrophy ( xref ), overexpression of eIF3m in human cancer cell lines and colon cancer patient tissues ( xref ), as well as overexpression of eIF3c in testicular seminoma cells ( xref )."