IndraLab

Statements

UCHL1 inhibits CDKN1A. 4 / 4
| 4
reach
"One study showed that UCHL1 suppresses autophagic degradation of p21 WAF1/Cip1 in cardiac fibroblasts via increasing mTOR activity [ 20 ]."
29462615
reach
"One study showed that UCHL1 suppresses autophagic degradation of p21 WAF1/Cip1 in cardiac fibroblasts via increasing mTOR activity [ 20 ]."
29462615
reach
"Interestingly, further experiments of the team showed that UCHL1 increased the protein content of p21 by inhibiting the autophagy lysosomal degradation of p21 rather than by inhibiting the ubiquitin-proteasome system (Ref."
38525836
reach
"Thus, whether UCH-L1 regulates these molecular events to suppress autophagic clearance of p21 WAF1 and Cip1 proteins deserves further investigation in cardiac fibroblasts."
24732420