IndraLab

Statements

BAP1 inhibits cell growth. 14 / 16
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"Restoration of BAP1 inhibits cell growth in cancer cell lines that lack BAP1 (NCI-H226 cells) or express defective BAP1 (769-P cells) [XREF_BIBR, XREF_BIBR]."
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"BAP1 knockdown in vitro has resulted in decreased cell proliferation and mediation of apoptosis in MSTO211H, HMeso, and H2373 mesothelioma cell lines, and reintroduction of wild-type BAP1 in BAP1-null cell line NCI-H226 promoted cell growth, yet another study reported that this was counterbalanced by increased apoptosis, indicating that the consequences of in vitro manipulation may be cell type dependent [XREF_BIBR, XREF_BIBR]."
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"BAP1 enhances BRCA1 mediated inhibition of breast cancer cell growth and is the first nuclear localized ubiquitin carboxy-terminal hydrolase to be identified."
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"With the colony formation assay, we also found that WT BAP1 suppressed the anchorage independent cell growth of the MM cells with BAP1 deletion, whereas mutant BAP1 showed little or no reduced effect."
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"BAP1 enhances BRCA1 mediated suppression of cell growth in colony formation assays, and this suppression by BAP1 is augmented by its UCH enzymatic domain."
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"BAP1 has been reported to suppress cell growth through its catalytic activity and nuclear localization XREF_BIBR XREF_BIBR."
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"BAP1 overexpression also suppressed cell growth in the 769-P renal cancer cell line in vitro XREF_BIBR."
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"Again, depletion of either BAP1 or KLF5 did not significantly decreased MDA-MB-231 cell growth (XREF_SUPPLEMENTARY)."
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"That study also showed that BAP1 slows cell growth through altered G1-S checkpoint regulation."
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"In the absence of a carcinogenic insult however, BAP1 loss may not promote cell growth."
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"Early experiments found that BAP1 enhanced BRCA1 mediated inhibition of breast cancer cell growth."
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"BAP1 was originally discovered as a binding partner for BRCA1 [XREF_BIBR] and shown to inhibit cancer cell growth."
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"18 BAP1 reintroduction into two different BAP1 deficient ccRCC cell lines reduced cell growth."
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"26 BAP1 knockdown using small interfering RNA (siRNA) in MPM cell lines inhibited cell growth, and resulted in inactivation of HCF1 and downregulation of downstream E2F responsive genes."
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