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BAP1 inhibits cell growth. 24 / 26
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"BAP1 knockout enhances anchorage-independent cell growth in human mesothelial cells."
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"Whether BAP1 also affects E2F1 ubiquitination to regulate its activity and the expression of E2F1 downstream target genes remains to be clarified.Previous studies have demonstrated that the overexpres[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"BAP1 enhances BRCA1 mediated suppression of cell growth in colony formation assays, and this suppression by BAP1 is augmented by its UCH enzymatic domain."
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"BAP1 was originally discovered as a binding partner for BRCA1 [XREF_BIBR] and shown to inhibit cancer cell growth."
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"That study also showed that BAP1 slows cell growth through altered G1-S checkpoint regulation."
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"In a previous report, BAP1 increased cell growth, whereas abnormal activity of BAP1 inhibited cell growth in several cancers."
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"BAP1 can suppress cell growth through its catalytic activity and nuclear localization ( Dey et al., 2012; Ventii et al., 2008 )."
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"Restoration of BAP1 inhibits cell growth in cancer cell lines that lack BAP1 (NCI-H226 cells) or express defective BAP1 (769-P cells) [XREF_BIBR, XREF_BIBR]."
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"BAP1 has been reported to suppress cell growth through its catalytic activity and nuclear localization XREF_BIBR XREF_BIBR."
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"However, in the semi-soft agar colony formation assay, the number of colonies was significantly increased in the BAP1-KO cells (Fig. S1b), suggesting that BAP1 loss might enhance anchorage-independent cell growth in human mesothelial cells."
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"BAP1 enhances BRCA1-mediated inhibition of breast cancer cell growth and may be a tumor suppressor gene that functions in the BRCA1 growth control pathway ( Jensen et al., 1998 )."
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"18 BAP1 reintroduction into two different BAP1 deficient ccRCC cell lines reduced cell growth."
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"26 BAP1 knockdown using small interfering RNA (siRNA) in MPM cell lines inhibited cell growth, and resulted in inactivation of HCF1 and downregulation of downstream E2F responsive genes."
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"BAP1, the target gene of miR-141-3p, inhibits PI3K activity, thereby inhibiting cell growth in Drosophila and humans [72]."
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"BAP1 enhances BRCA1 mediated inhibition of breast cancer cell growth and is the first nuclear localized ubiquitin carboxy-terminal hydrolase to be identified."
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"BAP1 suppressed osteosarcoma cell growth and EMT."
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"Early experiments found that BAP1 enhanced BRCA1 mediated inhibition of breast cancer cell growth."
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"BAP1 knockdown in vitro has resulted in decreased cell proliferation and mediation of apoptosis in MSTO211H, HMeso, and H2373 mesothelioma cell lines, and reintroduction of wild-type BAP1 in BAP1-null cell line NCI-H226 promoted cell growth, yet another study reported that this was counterbalanced by increased apoptosis, indicating that the consequences of in vitro manipulation may be cell type dependent [XREF_BIBR, XREF_BIBR]."
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"Dysregulation of BAP1 leads to a decreased MYCN protein level and subsequently causes NB cell growth inhibition (Fig. 6) and resistance to JQ1 and Alisertib treatment (Fig. 6)."
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"BAP1 overexpression also suppressed cell growth in the 769-P renal cancer cell line in vitro XREF_BIBR."
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"However, the loss of BAP1 leads to a substantial acceleration of B cell lymphoma cell growth in immunocompetent mice, indicating that BAP1 may function as a tumor suppressor via regulating TME and tumor immune response in this context.Decrease or loss of MHC-II expression in B cell lymphoma has been associated with genetic alterations, such as CIITA deficiency, and is associated with poor survival in human B cell lymphoma."
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"In the absence of a carcinogenic insult however, BAP1 loss may not promote cell growth."
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"Again, depletion of either BAP1 or KLF5 did not significantly decreased MDA-MB-231 cell growth (XREF_SUPPLEMENTARY)."
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"With the colony formation assay, we also found that WT BAP1 suppressed the anchorage independent cell growth of the MM cells with BAP1 deletion, whereas mutant BAP1 showed little or no reduced effect."
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